Nano-sized clusters of a teicoplanin ψ-aglycon-fullerene conjugate. Synthesis, antibacterial activity and aggregation studies

Szilvia Tollas, Ilona Bereczki, Attila Sipos, Erzsébet Rth, Gyula Batta, Lajos Daróczi, Sándor Kéki, Eszter Ostorházi, Ferenc Rozgonyi, Pál Herczegh

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Glycopeptide antibiotic derivative teicoplanin ψ-aglycone has been bound covalently to a fullerenopyrrolidine derivative using azide-alkyne 1,3-dipolar cycloaddition reaction. The aggregation of the antibiotic-fullerene conjugate in aqueous solution has been studied. The conjugate exhibited antibacterial activity against enterococci resistant to teicoplanin.

Original languageEnglish
Pages (from-to)943-948
Number of pages6
JournalEuropean Journal of Medicinal Chemistry
Volume54
DOIs
Publication statusPublished - Aug 1 2012

Keywords

  • 1,3-Dipolar cycloaddition
  • Fullerene
  • Multivalent aggregates
  • Teicoplanin ψ-aglycone

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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