Naltrexone potentiates 4-aminopyridine seizures in the rat

A. Mihály, K. Bencsik, T. Solymosi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The effects of a pharmacological blockade of the mu opiate receptors on the manifestation of tonic-clonic seizures were investigated in freely moving animals. 4-aminopyridine, a specific blocker of the neuronal K+ channels was used to produce generalized convulsions. After pretreatment of adult rats with 1 mg/kg naltrexone HCl, 3, 5, 7, 9, 14 mg/kg 4-aminopyridine was injected intraperitoneally, and the latencies of the symptoms generated by 4-aminopyridine were measured. Naltrexone HCl decreased these latencies and enhanced the seizures significantly. The experiments provided further evidence for the existence of a tonic anticonvulsant opioid system in the brain.

Original languageEnglish
Pages (from-to)59-67
Number of pages9
JournalJournal of Neural Transmission
Volume79
Issue number1-2
DOIs
Publication statusPublished - Feb 1990

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4-Aminopyridine
Naltrexone
Seizures
mu Opioid Receptor
Opioid Receptors
Anticonvulsants
Opioid Analgesics
Pharmacology
Brain

Keywords

  • Aminopyridine
  • naltrexone
  • opiate receptors
  • seizure

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Naltrexone potentiates 4-aminopyridine seizures in the rat. / Mihály, A.; Bencsik, K.; Solymosi, T.

In: Journal of Neural Transmission, Vol. 79, No. 1-2, 02.1990, p. 59-67.

Research output: Contribution to journalArticle

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