Naltrexone potentiates 4-aminopyridine seizures in the rat

A. Mihály, K. Bencsik, T. Solymosi

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Abstract

The effects of a pharmacological blockade of the mu opiate receptors on the manifestation of tonic-clonic seizures were investigated in freely moving animals. 4-aminopyridine, a specific blocker of the neuronal K+ channels was used to produce generalized convulsions. After pretreatment of adult rats with 1 mg/kg naltrexone HCl, 3, 5, 7, 9, 14 mg/kg 4-aminopyridine was injected intraperitoneally, and the latencies of the symptoms generated by 4-aminopyridine were measured. Naltrexone HCl decreased these latencies and enhanced the seizures significantly. The experiments provided further evidence for the existence of a tonic anticonvulsant opioid system in the brain.

Original languageEnglish
Pages (from-to)59-67
Number of pages9
JournalJournal of neural transmission
Volume79
Issue number1-2
DOIs
Publication statusPublished - Feb 1 1990

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Keywords

  • Aminopyridine
  • naltrexone
  • opiate receptors
  • seizure

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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