Naloxone reversal of the pentobarbital induced blockade of ovulation in the rat

J. Marton, J. Molnár, K. Köves, B. Halász

Research output: Contribution to journalArticle

5 Citations (Scopus)


The effect of naloxone, an opiate antagonist, on the pentobarbital induced suppression of gonadotrophin secretion and subsequent ovulation was studied. Two injections of naloxone, the first at 13.00 h and the second, given simultaneously with an ovulatory blocking dose of pentobarbital at 13.30 h, partially reversed the inhibitory effect of the barbiturate. However, if the first injection of naloxone was given with pentobarbital at 13.30 h and a second at 14.30 h, then the opioid antagonist had no such effect. Naloxone administered alone, enhanced gonadotrophin secretion and increased the number of ova shed. These findings support the view, that endogenous opioids may exert an inhibitory influence on central neural processes involved with ovulation.

Original languageEnglish
Pages (from-to)737-743
Number of pages7
JournalLife sciences
Issue number7
Publication statusPublished - Feb 16 1981

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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