Nafion-coated electrodes with high selectivity for CNS electrochemistry

Greg A. Gerhardt, Arvin F. Oke, G. Nagy, Bita Moghaddam, Ralph N. Adams

Research output: Contribution to journalArticle

543 Citations (Scopus)

Abstract

A major improvement in the selectivity of small graphite electrodes used for in vivo electrochemistry is described. The electrodes are coated with Nafion, a perfluorosulfonated polymer. This coating is practically impermeable to ascorbic acid and anionic biogenic amine metabolites and only slightly responsive to neutral metabolites. Thus it becomes selective for the cationic primary neurotransmitters, dopamine, norepinephrine and 5-hydroxytryptamine. Responses of Nafion-coated and untreated electrodes in vivo are compared.

Original languageEnglish
Pages (from-to)390-395
Number of pages6
JournalBrain Research
Volume290
Issue number2
DOIs
Publication statusPublished - Jan 9 1984

Fingerprint

Electrochemistry
Electrodes
Biogenic Amines
Graphite
Ascorbic Acid
Neurotransmitter Agents
Dopamine
Serotonin
Norepinephrine
Polymers
perfluorosulfonic acid

Keywords

  • in vivo electrochemistry
  • Nafion-coated electrodes

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Nafion-coated electrodes with high selectivity for CNS electrochemistry. / Gerhardt, Greg A.; Oke, Arvin F.; Nagy, G.; Moghaddam, Bita; Adams, Ralph N.

In: Brain Research, Vol. 290, No. 2, 09.01.1984, p. 390-395.

Research output: Contribution to journalArticle

Gerhardt, Greg A. ; Oke, Arvin F. ; Nagy, G. ; Moghaddam, Bita ; Adams, Ralph N. / Nafion-coated electrodes with high selectivity for CNS electrochemistry. In: Brain Research. 1984 ; Vol. 290, No. 2. pp. 390-395.
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