N-phenylpyrrole

A kinetic, though not thermodynamic preference for dilithiation

F. Faigl, Manfred Schlosser

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Under appropriate conditions the clean preparation of either the α-monolithiated or the o,α-dilithiated derivative of N-phenylpyrrole is possible. In the latter case, the first deprotonation occurs at the α-position. Dimetalation is kinetically but not thermodynamically favored.

Original languageEnglish
Pages (from-to)10271-10278
Number of pages8
JournalTetrahedron
Volume49
Issue number45
DOIs
Publication statusPublished - 1993

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Deprotonation
Thermodynamics
Derivatives
Kinetics
N-phenylpyrrole

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

N-phenylpyrrole : A kinetic, though not thermodynamic preference for dilithiation. / Faigl, F.; Schlosser, Manfred.

In: Tetrahedron, Vol. 49, No. 45, 1993, p. 10271-10278.

Research output: Contribution to journalArticle

Faigl, F. ; Schlosser, Manfred. / N-phenylpyrrole : A kinetic, though not thermodynamic preference for dilithiation. In: Tetrahedron. 1993 ; Vol. 49, No. 45. pp. 10271-10278.
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