N-phenylpyrrole: A kinetic, though not thermodynamic preference for dilithiation

Ferenc Faigl, Manfred Schlosser

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39 Citations (Scopus)

Abstract

Under appropriate conditions the clean preparation of either the α-monolithiated or the o,α-dilithiated derivative of N-phenylpyrrole is possible. In the latter case, the first deprotonation occurs at the α-position. Dimetalation is kinetically but not thermodynamically favored.

Original languageEnglish
Pages (from-to)10271-10278
Number of pages8
JournalTetrahedron
Volume49
Issue number45
DOIs
Publication statusPublished - 1993

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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