N-glycosylthioureido aglyco-ristocetins without platelet aggregation activity

F. Sztaricskai, Gábor Pintér, Erzsébet Röth, P. Herczegh, Szilvia Kardos, F. Rozgonyi, Z. Boda

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The water-soluble N-methoxy-PEG-yl-, N-β-D-glucopyranosyl- and N-β-D-maltosylthioureido aglycoristocetin were prepared which, in contrast to ristocetin A, did not induce thrombocyte aggregation. The antibacterial activity of N-β-D-maltosylthioureido aglyco-ristocetin A against MRSA was comparable to that of ristocetin A, while its activity against Enterococcus faecalis (VRE, TSE) is somewhat stronger when compared to those of vancomycin and ristocetin A.

Original languageEnglish
Pages (from-to)529-533
Number of pages5
JournalJournal of Antibiotics
Volume60
Issue number8
DOIs
Publication statusPublished - Aug 2007

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Ristocetin
Platelet Aggregation
Enterococcus faecalis
Vancomycin
Methicillin-Resistant Staphylococcus aureus
Blood Platelets
ristocetin A
Water

Keywords

  • Antibacterial activity
  • Glycopeptide antibiotics
  • Platelet aggregation
  • Synthesis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Molecular Medicine

Cite this

N-glycosylthioureido aglyco-ristocetins without platelet aggregation activity. / Sztaricskai, F.; Pintér, Gábor; Röth, Erzsébet; Herczegh, P.; Kardos, Szilvia; Rozgonyi, F.; Boda, Z.

In: Journal of Antibiotics, Vol. 60, No. 8, 08.2007, p. 529-533.

Research output: Contribution to journalArticle

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AU - Rozgonyi, F.

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