N-glycosylthioureido aglyco-ristocetins without platelet aggregation activity

Ferenc Sztaricskai, Gábor Pintér, Erzsébet Röth, Pál Herczegh, Szilvia Kardos, Ferenc Rozgonyi, Zoltán Boda

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The water-soluble N-methoxy-PEG-yl-, N-β-D-glucopyranosyl- and N-β-D-maltosylthioureido aglycoristocetin were prepared which, in contrast to ristocetin A, did not induce thrombocyte aggregation. The antibacterial activity of N-β-D-maltosylthioureido aglyco-ristocetin A against MRSA was comparable to that of ristocetin A, while its activity against Enterococcus faecalis (VRE, TSE) is somewhat stronger when compared to those of vancomycin and ristocetin A.

Original languageEnglish
Pages (from-to)529-533
Number of pages5
JournalJournal of Antibiotics
Volume60
Issue number8
DOIs
Publication statusPublished - Aug 1 2007

Keywords

  • Antibacterial activity
  • Glycopeptide antibiotics
  • Platelet aggregation
  • Synthesis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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