N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis

Ole A. Andreassen, Alpaslan Dedeoglu, P. Klivényi, M. Flint Beal, Ashley I. Bush

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Increasing evidence implicates oxidative damage as a major mechanism in the pathogenesis of amyotrophic lateral sclerosis (ALS). We examined the effect of preventative treatment with N-acetyl-L-cysteine (NAC), an agent that reduces free radical damage, in transgenic mice with a superoxide dismutase (SODI) mutation (G93A), used as an animal model of familial ALS. NAC was administered at 1% concentration in the drinking water from 4-5 weeks of age. The treatment caused a significantly prolonged survival and delayed onset of motor impairment in G93A mice treated with NAC compared to control mice. These results provide further evidence for the involvement of free radical damage in the G93A mice, and support the possibility that NAC, an over-the-counter antioxidant, could be explored in clinical trials for ALS. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)2491-2493
Number of pages3
JournalNeuroReport
Volume11
Issue number11
Publication statusPublished - Aug 3 2000

Fingerprint

Acetylcysteine
Animal Models
Amyotrophic Lateral Sclerosis
Free Radicals
Drinking Water
Transgenic Mice
Superoxide Dismutase
Antioxidants
Clinical Trials
Mutation
Amyotrophic lateral sclerosis 1

Keywords

  • Copper
  • Copper/zinc superoxide dismutase
  • Familial amyotrophic lateral sclerosis
  • Free radicals
  • N-acetyl cysteine
  • Oxidation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis. / Andreassen, Ole A.; Dedeoglu, Alpaslan; Klivényi, P.; Beal, M. Flint; Bush, Ashley I.

In: NeuroReport, Vol. 11, No. 11, 03.08.2000, p. 2491-2493.

Research output: Contribution to journalArticle

Andreassen, Ole A. ; Dedeoglu, Alpaslan ; Klivényi, P. ; Beal, M. Flint ; Bush, Ashley I. / N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis. In: NeuroReport. 2000 ; Vol. 11, No. 11. pp. 2491-2493.
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