Myocardium selective densitometric perfusion assessment after acute myocardial infarction

Tamás Ungi, Imre Ungi, Zsuzsanna Jónás, Viktor Sasi, András Lassó, Zsolt Zimmermann, T. Forster, András Palkó, Attila Nemes

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Myocardial perfusion is an important prognostic factor after recanalisation in acute myocardial infarction patients. We present a computerized, densitometric measurement method to assess myocardial perfusion on phase-matched digitally subtracted coronary angiograms. Methods and materials: Quantitative myocardial perfusion was assessed by the Gmax/Tmax parameter of the time-density curves (TDCs) in infarct-related myocardial regions on X-ray coronary angiograms. Arteries were masked out from regions of measurement. This novel method has been compared with enzymatic infarct size, ST-segment resolution, and ejection fraction after successful revascularization of 62 patients with acute myocardial infarction. Results: Significant correlations were found between Gmax/Tmax and enzymatic infarct size (R=-0.445, Pmax/Tmax reveals good interobserver agreement. Conclusions: Gmax/Tmax of the TDC measured in the infarct-related myocardial area is a reliable parameter to assess clinical indicators of myocardial reperfusion. Therefore, results suggest that it could be used to immediately assess the success of recanalisation at the tissue perfusion level during coronary intervention, and as an objective end point in clinical trials of new interventional devices and drugs.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalCardiovascular Revascularization Medicine
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 2009

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Myocardium
Perfusion
Myocardial Infarction
Angiography
Myocardial Reperfusion
Arteries
X-Rays
Clinical Trials
Equipment and Supplies
Pharmaceutical Preparations

Keywords

  • Acute myocardial infarction
  • Cineangiography
  • Myocardial viability

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Myocardium selective densitometric perfusion assessment after acute myocardial infarction. / Ungi, Tamás; Ungi, Imre; Jónás, Zsuzsanna; Sasi, Viktor; Lassó, András; Zimmermann, Zsolt; Forster, T.; Palkó, András; Nemes, Attila.

In: Cardiovascular Revascularization Medicine, Vol. 10, No. 1, 01.2009, p. 49-54.

Research output: Contribution to journalArticle

Ungi, T, Ungi, I, Jónás, Z, Sasi, V, Lassó, A, Zimmermann, Z, Forster, T, Palkó, A & Nemes, A 2009, 'Myocardium selective densitometric perfusion assessment after acute myocardial infarction', Cardiovascular Revascularization Medicine, vol. 10, no. 1, pp. 49-54. https://doi.org/10.1016/j.carrev.2008.10.001
Ungi, Tamás ; Ungi, Imre ; Jónás, Zsuzsanna ; Sasi, Viktor ; Lassó, András ; Zimmermann, Zsolt ; Forster, T. ; Palkó, András ; Nemes, Attila. / Myocardium selective densitometric perfusion assessment after acute myocardial infarction. In: Cardiovascular Revascularization Medicine. 2009 ; Vol. 10, No. 1. pp. 49-54.
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