A myocardium-prekondicionálás és gyakorlati jelentósége.

Translated title of the contribution: Myocardial preconditioning and its practical significance

László Hejjel, Erzsébet Röth

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The authors review the history and physiological basis of myocardial preconditioning including its receptors, signalization and effectors. The classical and delayed (second window) type of preconditioning and relations of the latter to heat shock proteins are discussed. Preconditioning as a form of endogenous adaptation effectively reduces the degree of myocardial injury during a subsequent ischaemia in experimental models and in human as well. Intentional triggering or augmentation of the condition may become a new therapeutic tool in the treatment of ischaemic diseases. Utilizing the advantages of endogen adaptation, the optimal drug or procedure to be applied in the routine clinical practice will come out in the future considering its efficacy and the safety and convenience of the patient.

Original languageHungarian
Pages (from-to)587-594
Number of pages8
JournalOrvosi hetilap
Volume143
Issue number12
Publication statusPublished - Mar 24 2002

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ASJC Scopus subject areas

  • Medicine(all)

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