Myocardial lipid peroxidation in rats after chronic alcohol ingestion and the effects of different antioxidants

I. Édes, Anna Tószegi, Miklós Csanady, Béla Bozóky

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

Summary: The effects of chronic intake of dietary alcohol on myocardial peroxidation (measured as formation of diene conjugates), reduced glutathione content, and morphology and the protective actions of different antioxidant compounds (vitamin E and (+)-cyanidanol-3) were studied in rats. Alcohol, comprising more than 30% of the dietary calorie content, was administered to rats for six weeks. Compared with the controls, the left ventricle of the alcoholic animals had an increased diene conjugate content (5.4(0.5) vs 4.3(0.6) optical density·g wet weight-1) and a slightly, but not significantly, decreased glutathione content (1.62(0.05) vs 1.66(0.07) μmol·g wet weight-1). Simultaneous administration of antioxidants (vitamin E or (+)-cyanidanol-3) prevented the pathological changes in diene conjugates and significantly increased the glutathione content compared with the alcoholic rats. Electron microscopy showed remarkably few ultrastructural abnormalities in the myocardium of alcoholic animals fixed by vascular perfusion.The data are consistent with the hypothesis that reactive oxygen radicals are involved in the ethanol induced biochemical changes and that the antioxidants could prevent the increased formation of peroxides in the myocardium.

Original languageEnglish
Pages (from-to)542-548
Number of pages7
JournalCardiovascular Research
Volume20
Issue number7
DOIs
Publication statusPublished - Jan 1 1986

Fingerprint

Lipid Peroxidation
Glutathione
Catechin
Eating
Antioxidants
Alcohols
Vitamin E
Myocardium
Weights and Measures
Peroxides
Heart Ventricles
Blood Vessels
Reactive Oxygen Species
Electron Microscopy
Ethanol
Perfusion

Keywords

  • Alcohol
  • Antioxidants
  • Diene conjugates
  • Glutathione
  • Lipids
  • Myocardium
  • Peroxidation
  • Vascular perfusion

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Myocardial lipid peroxidation in rats after chronic alcohol ingestion and the effects of different antioxidants. / Édes, I.; Tószegi, Anna; Csanady, Miklós; Bozóky, Béla.

In: Cardiovascular Research, Vol. 20, No. 7, 01.01.1986, p. 542-548.

Research output: Contribution to journalReview article

Édes, I. ; Tószegi, Anna ; Csanady, Miklós ; Bozóky, Béla. / Myocardial lipid peroxidation in rats after chronic alcohol ingestion and the effects of different antioxidants. In: Cardiovascular Research. 1986 ; Vol. 20, No. 7. pp. 542-548.
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