Myocardial infarction is associated with Sp1 binding site polymorphism of collagen type 1A1 gene

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15 Citations (Scopus)

Abstract

Objective - Human atherosclerotic lesions contain collagen type I, which plays a pivotal role in atherosclerotic plaque stability. In contrast, the normal coronary arteries do not express this type of collagen. Data have shown that the collagen type IAI (COLIAI) gene Sp1 binding site (-1245 G/T) polymorphism is associated with disturbed collagen protein production. Methods - In our study, COLIAI gene Sp1 polymorphism was investigated in 136 patients with myocardial infarction (Ml) 5 months after the acute phase, and 212 age-matched control subjects in association with any cardiovascular risk factors (such as serum adiponectin levels, hyperinsulinaemic status, hyperlipaemia). Results - The "SS" genotype of the COLIAI gene was found to occur significantly more frequently in patients surviving a MI, as compared to the control group and the "Ss" and "ss" genotype frequencies (the presence of the s allele) were lower in our patients, than in control group. However, the occurrence of cardiovascular risk factors was significantly higher among the "s" allelic carriers as compared to patients carrying the "S" allele of the COLIAI gene. Conclusion - Our results raise the possibility that COLIAI gene Sp1 polymorphism might have an impact on the development of MI.

Original languageEnglish
Pages (from-to)321-325
Number of pages5
JournalActa cardiologica
Volume61
Issue number3
DOIs
Publication statusPublished - Jun 1 2006

Keywords

  • Collagen
  • Genetics
  • Myocardial infarction
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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