Mycoplasma gallisepticum: Influence of cell invasiveness on the outcome of experimental infection in chickens

Peter Much, Florian Winner, László Stipkovits, Renate Rosengarten, Christine Citti

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Abstract

Recently we have shown that a low (Rlow) and a high laboratory passage (Rhigh) of the poultry pathogen Mycoplasma gallisepticum prototype strain R differ markedly in their capability to invade non-phagocytic eukaryotic cells. In the present study the infection traits of these two mycoplasma passages were compared in an in vivo setting. After aerosol inoculation of chickens, M. gallisepticum was re-isolated from the inner organs of birds infected with Rlow, whereas no mycoplasma was recovered from the inner organs of birds infected with Rhigh. These results indicate that the two mycoplasma populations derived from strain R differ in their capacity to cross the mucosal barrier and suggest that cell invasion may play a major role in the observed systemic spreading of M. gallisepticum in its chicken host.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalFEMS Immunology and Medical Microbiology
Volume34
Issue number3
DOIs
Publication statusPublished - Nov 15 2002

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Keywords

  • Cell invasion
  • Experimental infection
  • Host colonization
  • Mycoplasma
  • Respiratory disease
  • Systemic infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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