Myasthenia gravis: Lung-function studies without and with edrophonium chloride

P. Magyar, I. Szathmáry, A. Szobor

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

25 myasthenia gravis-afflicted patients (14 crisis-endangered and 11 not endangered) were investigated with respect to their respiratory function and reaction of the respiratory parameters to Tensilon® (edrophonium chloride). Results show that the vital capacity and the value of respiratory function parameters, measured under forced conditions, were partly significantly lower than those given as predicted values for healthy individuals. Maximal inspiratory flows indicated the greatest decrease. After intravenously administered Tensilon®, the pathologically reduced maximal inspiratory flows increased. This positive effect of Tensilon® can mark the alteration of the respiratory muscles and also the undertreatment of the patients. The observation that Tensilon® may increase-with some permanency-the respiratory flow resistance and may decrease the maximal expiratory flow values, draws attention to the side effect (causing obstruction of the bronchi) of the drug, limiting its therapeutic use for patients in myasthenic crisis, especially in those complicated by obstructive lung disease.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalEuropean Neurology
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 1 1979

Keywords

  • Crisis danger
  • Edrophonium chloride
  • Expiratory flow
  • Inspiratory flow
  • Lung function
  • Myasthenia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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