Myasthenia gravis: Demonstration of membrane attack complex in muscle end-plates

A. Fazekas, S. Komoly, B. Bozsik, A. Szobor

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The membrane attack complex (MAC) assembles from C5b-9 complement components and has neoantigenic properties. Antihuman-MAC rabbit immunserum was applied in order to localize the MAC in myasthenic muscles. Using the indirect immuneperoxidase method MAC was demonstrated at the motor end-plates in eleven myasthenic patients who underwent thymectomy. This result provides direct evidence of antibody-dependent complement-mediated injury of acetylcholine receptors in myasthenia gravis.

Original languageEnglish
Pages (from-to)78-83
Number of pages6
JournalClinical Neuropathology
Volume5
Issue number2
Publication statusPublished - Jan 1 1986

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology

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