Mutagenicity of synthetic acridinones and thioacridines in direct Ames' Salmonella mutagenicity assay

M. Tanaka, Klára Csúri, I. Mucsi, J. Molnár, J. P. Galy, Jacques Barbe

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Abstract

Newly synthesized antitrypanosomal and antiplasmid acridinones, thio-substituted acridines and thioacridinones were tested for a direct genotoxic effect on TA97a and TA100 tester strains by Ames' Salmonella mutagenicity assay. Of acridinones, only 9-(hydrazinothiazolo[5,4-a])acridinone 1 showed strong mutagenic activity on TA97a strain. However, mutagenic activity was manifested invariably by all three acridinones on TA100 strain. Of thioacridines, 2,7-dimethoxy-9-thioacridinone 4, 2,7-dimethoxy-9-(3'-aminopropyl) 5 and 2,7-dihydroxy-9-acetamidothioacridine 6 were explicitly mutagenic on TA97a, but on TA100 they were just weakly mutagenic.

Original languageEnglish
Pages (from-to)463-467
Number of pages5
JournalHeterocyclic Communications
Volume2
Issue number5
Publication statusPublished - 1996

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Salmonella
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Acridines

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  • Organic Chemistry

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Mutagenicity of synthetic acridinones and thioacridines in direct Ames' Salmonella mutagenicity assay. / Tanaka, M.; Csúri, Klára; Mucsi, I.; Molnár, J.; Galy, J. P.; Barbe, Jacques.

In: Heterocyclic Communications, Vol. 2, No. 5, 1996, p. 463-467.

Research output: Contribution to journalArticle

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AU - Tanaka, M.

AU - Csúri, Klára

AU - Mucsi, I.

AU - Molnár, J.

AU - Galy, J. P.

AU - Barbe, Jacques

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