Muscular and cardiorespiratory fitness are independently associated with metabolic risk in adolescents

The HELENA study

Enrique G. Artero, Jonatan R. Ruiz, Francisco B. Ortega, Vanesa España-Romero, Germán Vicente-Rodríguez, D. Molnár, Frederic Gottrand, Marcela González-Gross, Christina Breidenassel, Luis A. Moreno, Angel Gutiérrez

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Objective: To examine the independent associations of muscular and cardiorespiratory fitness with clustered metabolic risk in adolescents. Methods: Participants were 709 adolescents (346 boys) from 10 European centers, aged 12.5-17.5 yr, evaluated as a part of the Healthy Lifestyle in Europe by Nutrition in Adolescents cross-sectional study (HELENA-CSS). A muscular fitness score was computed using handgrip strength and standing long jump. Cardiorespiratory fitness was measured using the 20-m shuttle run test. Age- and gender-specific z-scores of waist circumference, systolic blood pressure, triglycerides, ratio total cholesterol/high-density lipoprotein cholesterol, and insulin resistance (homeostasis model assessment) were summed to create a metabolic risk score. Results: Muscular fitness was negatively associated with clustered metabolic risk independent of cardiorespiratory fitness (β = -0.249, p <0.001). Independent of muscular fitness, an inverse association was also found between cardiorespiratory fitness and clustered metabolic risk (β = 0.264, p <0.001). The odds ratios for having a high clustered risk (above or equal 1 standard deviation) were 5.3 [95% confidence interval (CI) = 2.6-10.6] and 4.3 (95% CI = 2.0-9.3) in the least fit quartile compared with the most fit quartile for muscular and cardiorespiratory fitness, respectively. Significant differences in metabolic risk between muscular fitness levels persisted among non-overweight (p = 0.012) and overweight participants (p = 0.011). Conclusion: Muscular and cardiorespiratory fitness are independently associated with metabolic risk in adolescents. These results support current physical activity recommendations for youth, which include muscle strengthening activities in addition to aerobic exercise.

Original languageEnglish
Pages (from-to)704-712
Number of pages9
JournalPediatric Diabetes
Volume12
Issue number8
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Senior Centers
Confidence Intervals
Exercise
Blood Pressure
Waist Circumference
Cardiorespiratory Fitness
HDL Cholesterol
Insulin Resistance
Triglycerides
Homeostasis
Cross-Sectional Studies
Odds Ratio
Cholesterol
Muscles
Healthy Lifestyle

Keywords

  • Adolescence
  • Cardiorespiratory fitness
  • Metabolic risk
  • Muscular fitness

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Cite this

Artero, E. G., Ruiz, J. R., Ortega, F. B., España-Romero, V., Vicente-Rodríguez, G., Molnár, D., ... Gutiérrez, A. (2011). Muscular and cardiorespiratory fitness are independently associated with metabolic risk in adolescents: The HELENA study. Pediatric Diabetes, 12(8), 704-712. https://doi.org/10.1111/j.1399-5448.2011.00769.x

Muscular and cardiorespiratory fitness are independently associated with metabolic risk in adolescents : The HELENA study. / Artero, Enrique G.; Ruiz, Jonatan R.; Ortega, Francisco B.; España-Romero, Vanesa; Vicente-Rodríguez, Germán; Molnár, D.; Gottrand, Frederic; González-Gross, Marcela; Breidenassel, Christina; Moreno, Luis A.; Gutiérrez, Angel.

In: Pediatric Diabetes, Vol. 12, No. 8, 12.2011, p. 704-712.

Research output: Contribution to journalArticle

Artero, EG, Ruiz, JR, Ortega, FB, España-Romero, V, Vicente-Rodríguez, G, Molnár, D, Gottrand, F, González-Gross, M, Breidenassel, C, Moreno, LA & Gutiérrez, A 2011, 'Muscular and cardiorespiratory fitness are independently associated with metabolic risk in adolescents: The HELENA study', Pediatric Diabetes, vol. 12, no. 8, pp. 704-712. https://doi.org/10.1111/j.1399-5448.2011.00769.x
Artero, Enrique G. ; Ruiz, Jonatan R. ; Ortega, Francisco B. ; España-Romero, Vanesa ; Vicente-Rodríguez, Germán ; Molnár, D. ; Gottrand, Frederic ; González-Gross, Marcela ; Breidenassel, Christina ; Moreno, Luis A. ; Gutiérrez, Angel. / Muscular and cardiorespiratory fitness are independently associated with metabolic risk in adolescents : The HELENA study. In: Pediatric Diabetes. 2011 ; Vol. 12, No. 8. pp. 704-712.
@article{f175054bc66f435299b793a2734a87f1,
title = "Muscular and cardiorespiratory fitness are independently associated with metabolic risk in adolescents: The HELENA study",
abstract = "Objective: To examine the independent associations of muscular and cardiorespiratory fitness with clustered metabolic risk in adolescents. Methods: Participants were 709 adolescents (346 boys) from 10 European centers, aged 12.5-17.5 yr, evaluated as a part of the Healthy Lifestyle in Europe by Nutrition in Adolescents cross-sectional study (HELENA-CSS). A muscular fitness score was computed using handgrip strength and standing long jump. Cardiorespiratory fitness was measured using the 20-m shuttle run test. Age- and gender-specific z-scores of waist circumference, systolic blood pressure, triglycerides, ratio total cholesterol/high-density lipoprotein cholesterol, and insulin resistance (homeostasis model assessment) were summed to create a metabolic risk score. Results: Muscular fitness was negatively associated with clustered metabolic risk independent of cardiorespiratory fitness (β = -0.249, p <0.001). Independent of muscular fitness, an inverse association was also found between cardiorespiratory fitness and clustered metabolic risk (β = 0.264, p <0.001). The odds ratios for having a high clustered risk (above or equal 1 standard deviation) were 5.3 [95{\%} confidence interval (CI) = 2.6-10.6] and 4.3 (95{\%} CI = 2.0-9.3) in the least fit quartile compared with the most fit quartile for muscular and cardiorespiratory fitness, respectively. Significant differences in metabolic risk between muscular fitness levels persisted among non-overweight (p = 0.012) and overweight participants (p = 0.011). Conclusion: Muscular and cardiorespiratory fitness are independently associated with metabolic risk in adolescents. These results support current physical activity recommendations for youth, which include muscle strengthening activities in addition to aerobic exercise.",
keywords = "Adolescence, Cardiorespiratory fitness, Metabolic risk, Muscular fitness",
author = "Artero, {Enrique G.} and Ruiz, {Jonatan R.} and Ortega, {Francisco B.} and Vanesa Espa{\~n}a-Romero and Germ{\'a}n Vicente-Rodr{\'i}guez and D. Moln{\'a}r and Frederic Gottrand and Marcela Gonz{\'a}lez-Gross and Christina Breidenassel and Moreno, {Luis A.} and Angel Guti{\'e}rrez",
year = "2011",
month = "12",
doi = "10.1111/j.1399-5448.2011.00769.x",
language = "English",
volume = "12",
pages = "704--712",
journal = "Pediatric Diabetes",
issn = "1399-543X",
publisher = "Blackwell Munksgaard",
number = "8",

}

TY - JOUR

T1 - Muscular and cardiorespiratory fitness are independently associated with metabolic risk in adolescents

T2 - The HELENA study

AU - Artero, Enrique G.

AU - Ruiz, Jonatan R.

AU - Ortega, Francisco B.

AU - España-Romero, Vanesa

AU - Vicente-Rodríguez, Germán

AU - Molnár, D.

AU - Gottrand, Frederic

AU - González-Gross, Marcela

AU - Breidenassel, Christina

AU - Moreno, Luis A.

AU - Gutiérrez, Angel

PY - 2011/12

Y1 - 2011/12

N2 - Objective: To examine the independent associations of muscular and cardiorespiratory fitness with clustered metabolic risk in adolescents. Methods: Participants were 709 adolescents (346 boys) from 10 European centers, aged 12.5-17.5 yr, evaluated as a part of the Healthy Lifestyle in Europe by Nutrition in Adolescents cross-sectional study (HELENA-CSS). A muscular fitness score was computed using handgrip strength and standing long jump. Cardiorespiratory fitness was measured using the 20-m shuttle run test. Age- and gender-specific z-scores of waist circumference, systolic blood pressure, triglycerides, ratio total cholesterol/high-density lipoprotein cholesterol, and insulin resistance (homeostasis model assessment) were summed to create a metabolic risk score. Results: Muscular fitness was negatively associated with clustered metabolic risk independent of cardiorespiratory fitness (β = -0.249, p <0.001). Independent of muscular fitness, an inverse association was also found between cardiorespiratory fitness and clustered metabolic risk (β = 0.264, p <0.001). The odds ratios for having a high clustered risk (above or equal 1 standard deviation) were 5.3 [95% confidence interval (CI) = 2.6-10.6] and 4.3 (95% CI = 2.0-9.3) in the least fit quartile compared with the most fit quartile for muscular and cardiorespiratory fitness, respectively. Significant differences in metabolic risk between muscular fitness levels persisted among non-overweight (p = 0.012) and overweight participants (p = 0.011). Conclusion: Muscular and cardiorespiratory fitness are independently associated with metabolic risk in adolescents. These results support current physical activity recommendations for youth, which include muscle strengthening activities in addition to aerobic exercise.

AB - Objective: To examine the independent associations of muscular and cardiorespiratory fitness with clustered metabolic risk in adolescents. Methods: Participants were 709 adolescents (346 boys) from 10 European centers, aged 12.5-17.5 yr, evaluated as a part of the Healthy Lifestyle in Europe by Nutrition in Adolescents cross-sectional study (HELENA-CSS). A muscular fitness score was computed using handgrip strength and standing long jump. Cardiorespiratory fitness was measured using the 20-m shuttle run test. Age- and gender-specific z-scores of waist circumference, systolic blood pressure, triglycerides, ratio total cholesterol/high-density lipoprotein cholesterol, and insulin resistance (homeostasis model assessment) were summed to create a metabolic risk score. Results: Muscular fitness was negatively associated with clustered metabolic risk independent of cardiorespiratory fitness (β = -0.249, p <0.001). Independent of muscular fitness, an inverse association was also found between cardiorespiratory fitness and clustered metabolic risk (β = 0.264, p <0.001). The odds ratios for having a high clustered risk (above or equal 1 standard deviation) were 5.3 [95% confidence interval (CI) = 2.6-10.6] and 4.3 (95% CI = 2.0-9.3) in the least fit quartile compared with the most fit quartile for muscular and cardiorespiratory fitness, respectively. Significant differences in metabolic risk between muscular fitness levels persisted among non-overweight (p = 0.012) and overweight participants (p = 0.011). Conclusion: Muscular and cardiorespiratory fitness are independently associated with metabolic risk in adolescents. These results support current physical activity recommendations for youth, which include muscle strengthening activities in addition to aerobic exercise.

KW - Adolescence

KW - Cardiorespiratory fitness

KW - Metabolic risk

KW - Muscular fitness

UR - http://www.scopus.com/inward/record.url?scp=82155178883&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82155178883&partnerID=8YFLogxK

U2 - 10.1111/j.1399-5448.2011.00769.x

DO - 10.1111/j.1399-5448.2011.00769.x

M3 - Article

VL - 12

SP - 704

EP - 712

JO - Pediatric Diabetes

JF - Pediatric Diabetes

SN - 1399-543X

IS - 8

ER -