Muscle biopsy is a frequently used diagnostic procedure in cases of suspected myopathies. Although recently introduced non-invasive blood genetic tests can replace muscle histology in certain diseases (e.g. infantile spinal muscular atrophy), it remains the gold standard in the assessment of myopathies either inherited or acquired origin.We retrospectively analyzed the neuromuscular database of the Neurology Department of University of Pecs, Hungary, between 2000-2010. We reviewed the muscle biopsy reports of 970 biopsy specimens performed in this period. The corresponding medical records were revised as well.The most frequent histological diagnosis was myopathy-dystrophy in 53% of all cases. Neurogenic muscle atrophy and mixed myopathic-neurogenic pathology were found in 18%. Myositis was confirmed in 9%. Biopsy was negative or resulted in non-specific changes in the remaining cases (20%). The number of biopsies/year decreased in the last few years, and the ratio of negative results and neurogenic disorders is reduced significantly as well.In this review, we discuss the indications and diagnostic yield of muscle biopsy, the most frequent types and characteristic histological findings of myopathies. We present the routine procedures and histological techniques.
|Title of host publication||Myopathies|
|Subtitle of host publication||New Research|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||17|
|Publication status||Published - Jan 1 2013|
ASJC Scopus subject areas