Muscarinic cholinergic effects on stimulus-evoked responses in rat primary somatosensory cortex. An electrophysiological study.

T. Farkas, K. Kóródi, J. Toldi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Neuron terminals originating from the nucleus basalis megnocellularis (NBM) are the major source of the cortical cholinergic innervation, which is thought to play an essential role in higher brain functions. Electrophysiological studies have shown that activation of muscarinic cholinergic receptors caused a marked enhancement of sensory stimuli onto cortical neurons. Diminished cholinergic innervation of somatosensory cortical areas are manifested in decreased stimulus-evoked activity and impaired performance in a sensory discrimination task. We examined the effects of ACh and its muscarinic agonists on the response properties of layer IV-V barrel cortex neurons evoked by precisely controlled vibriasa deflections. The cholinergic pharmacons displayed their mostly facilitatory effects in latency-dependent manner: In most cases only one latency component of On and/or Off responses were changed.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalActa Biologica Hungarica
Volume47
Issue number1-4
Publication statusPublished - 1996

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Somatosensory Cortex
cholinergic agents
Cholinergic Agents
Rats
cortex
neurons
innervation
Neurons
rats
deflection
brain
Muscarinic Agonists
cholinergic receptors
Cholinergic Receptors
Muscarinic Receptors
agonists
Brain
Chemical activation
effect

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

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