Muscarinic autoreceptors are differentially affected by selective muscarinic antagonists in rat hippocampus

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6 Citations (Scopus)

Abstract

The effects of atropine, pirenzepine and AF-DX 116 on the high K+-evoked release of endogenous ACh from rat hippocampal slices were compared. As expected, atropine in concentrations of 10-5 and 10-6M increased the release of acetylcholine, to 128 and 157% of the control value, respectively. While AF-DX 116 was also able to increase the release to 148 and 156% of the control value at the above concentrations, pirenzepine had no effect on the release. This may indicate that no M1 receptors are involved in the control of presynaptic acetylcholine release, probably because of their postsynaptic localization, and that the presynaptic muscarinic cholinergic autoreceptors are equivalent to the M2 receptors in rat hippocampus.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalNeurochemistry International
Volume15
Issue number2
DOIs
Publication statusPublished - 1989

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Pirenzepine
Autoreceptors
Muscarinic Antagonists
Atropine
Cholinergic Agents
Acetylcholine
Hippocampus
otenzepad

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

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title = "Muscarinic autoreceptors are differentially affected by selective muscarinic antagonists in rat hippocampus",
abstract = "The effects of atropine, pirenzepine and AF-DX 116 on the high K+-evoked release of endogenous ACh from rat hippocampal slices were compared. As expected, atropine in concentrations of 10-5 and 10-6M increased the release of acetylcholine, to 128 and 157{\%} of the control value, respectively. While AF-DX 116 was also able to increase the release to 148 and 156{\%} of the control value at the above concentrations, pirenzepine had no effect on the release. This may indicate that no M1 receptors are involved in the control of presynaptic acetylcholine release, probably because of their postsynaptic localization, and that the presynaptic muscarinic cholinergic autoreceptors are equivalent to the M2 receptors in rat hippocampus.",
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AU - Gulya, K.

AU - Budai, D.

AU - Kása, P.

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AB - The effects of atropine, pirenzepine and AF-DX 116 on the high K+-evoked release of endogenous ACh from rat hippocampal slices were compared. As expected, atropine in concentrations of 10-5 and 10-6M increased the release of acetylcholine, to 128 and 157% of the control value, respectively. While AF-DX 116 was also able to increase the release to 148 and 156% of the control value at the above concentrations, pirenzepine had no effect on the release. This may indicate that no M1 receptors are involved in the control of presynaptic acetylcholine release, probably because of their postsynaptic localization, and that the presynaptic muscarinic cholinergic autoreceptors are equivalent to the M2 receptors in rat hippocampus.

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