Muscarinic and nicotinic cholinergic agonists: Structural analogies and discrepancies

Zsolt Bikádi, M. Simonyi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Acetylcholine, the first identified neurotransmitter acts on both types of cholinergic receptors. Both rigid and flexible derivatives of acetylcholine could either be selective muscarinic or selective nicotinic agonists while some compounds show activity at both receptor subclasses. Earlier structure-activity considerations are revisited. Ligand and receptor based calculations have been applied in the hope to identify characteristic geometrical and steric requirements for the activity on the receptor subtypes. Results are treated critically and applied cautiously for predicting selective structural requirements by the cholinergic receptor subclasses.

Original languageEnglish
Pages (from-to)2611-2620
Number of pages10
JournalCurrent Medicinal Chemistry
Volume10
Issue number23
DOIs
Publication statusPublished - 2003

Fingerprint

Nicotinic Agonists
Muscarinic Agonists
Cholinergic Receptors
Acetylcholine
Cholinergic Agents
Neurotransmitter Agents
Ligands
Derivatives

Keywords

  • Acetylcholine conformation
  • Cholinergic agonist
  • Docking
  • Heteroatomic distances
  • Muscarinic selectivity
  • Nicotinic selectivity
  • Steric exclusion
  • Torsion angle

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Pharmacology

Cite this

Muscarinic and nicotinic cholinergic agonists : Structural analogies and discrepancies. / Bikádi, Zsolt; Simonyi, M.

In: Current Medicinal Chemistry, Vol. 10, No. 23, 2003, p. 2611-2620.

Research output: Contribution to journalArticle

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