Multistep continuous-flow synthesis of condensed benzothiazoles

Klára Lövei, István Greiner, János Éles, Áron Szigetvári, Miklós Dékány, Sándor Lévai, Z. Novák, György István Túrós

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In medicinal chemistry, the development of synthetic procedures for the access of new heterocyclic systems as potential scaffolds is elementary. Herein, we report our results on the formation of small drug-like heterocycles, utilizing flow chemistry. This approach enables the extension of the reaction parameter window, including high-pressure/high-temperature or hazardous chemistry. In our work, various novel condensed tricyclic benzothiazoles fused with furo- And thieno-rings were synthesized applying a multistep continuous-flow protocol. The process includes two ring closure steps and a nitro group reduction step. Batch and telescoped continuous-flow syntheses were also designed and performed.

Original languageEnglish
Pages (from-to)74-81
Number of pages8
JournalJournal of Flow Chemistry
Volume5
Issue number2
DOIs
Publication statusPublished - Jun 1 2015

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Keywords

  • Benzothiazoles
  • Catalytic hydrogenation
  • Condensed heterocycles
  • Flow chemistry
  • Ring formation

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Fluid Flow and Transfer Processes
  • Organic Chemistry

Cite this

Lövei, K., Greiner, I., Éles, J., Szigetvári, Á., Dékány, M., Lévai, S., Novák, Z., & Túrós, G. I. (2015). Multistep continuous-flow synthesis of condensed benzothiazoles. Journal of Flow Chemistry, 5(2), 74-81. https://doi.org/10.1556/1846.2015.00004