In our days peripheral arterial disease is an undiagnosed disorder. Several suggestible and non-suggestible risk factors have role in its development and progression. As system disorder it might be a part and an important predictor of fatal cardio- and cerebrovascular events. Case report: The authors describe a 73-year-old male's case as illustrative example of multilocularity of disorder occurring simultaneously with carotid disease, critical limb ischaemia with aorto-bifemoral bypass, multiple infarctus with mechanical complication, inoperable coronary status and ventricular rhythm indicated implantable cardioverter defibrillator. Conclusion: Peripheral arterial disease affects the whole vascular system and cap progrediate into serious cardial and cerebal manifestation causing patient death despite complex and deliberate treatment.
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