Multiple use of a signal transduction pathway in tumor cell invasion

J. Tímár, E. Rásó, Zs Fazakas, S. Silletti, A. Raz, K. V. Honn

Research output: Contribution to journalArticle

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Abstract

Recent reports have indicated that a poorly characterized signaling pathway involving 12-lipoxygenase and PKC is involved in several steps of the metastatic cascade such as tumor cell adhesion to matrix lysosomal enzyme release and migration. Recent reports have indicated that a poorly characterized signaling pathway involving 12-lipoxygenase and PKC is involved in several strips of the metastatic cascade such as tumor cell adhesion to matrix, lysosomal enzyme release and migration. We investigated here the upstream elements of this signalling pathway looking for receptors which it might be coupled to. We described tumor cell αIIbβ3-like integrin and the AMF receptor, gp78, as two transmembrane receptors which utilize the 12-lipoxygenase/PKC signaling. Furthermore, we compared the in vivo expression of the signal components of the 'autocrine motility cycle' (gp78, 12-LOX and PKCa - Timar et al 1993) in human prostate carcinoma cell lines (PC3 and DU145) with different invasive potential We report here that all three components of this cycle are overexpressed three fold in vivo in the move aggressive tumor, suggesting that this signalling pathway might regulate the invasive phenotype - at least in the studied turner cells.

Original languageEnglish
Pages (from-to)3299-3306
Number of pages8
JournalAnticancer Research
Volume16
Issue number6 A
Publication statusPublished - 1996

Fingerprint

Arachidonate 12-Lipoxygenase
Signal Transduction
Cell-Matrix Junctions
Autocrine Motility Factor Receptor
Neoplasms
Enzymes
Integrins
Prostate
Carcinoma
Phenotype
Cell Line

Keywords

  • 12-lipoxygenase
  • AMF
  • Integrin
  • Melanoma invasion
  • PKC
  • Signalling

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Tímár, J., Rásó, E., Fazakas, Z., Silletti, S., Raz, A., & Honn, K. V. (1996). Multiple use of a signal transduction pathway in tumor cell invasion. Anticancer Research, 16(6 A), 3299-3306.

Multiple use of a signal transduction pathway in tumor cell invasion. / Tímár, J.; Rásó, E.; Fazakas, Zs; Silletti, S.; Raz, A.; Honn, K. V.

In: Anticancer Research, Vol. 16, No. 6 A, 1996, p. 3299-3306.

Research output: Contribution to journalArticle

Tímár, J, Rásó, E, Fazakas, Z, Silletti, S, Raz, A & Honn, KV 1996, 'Multiple use of a signal transduction pathway in tumor cell invasion', Anticancer Research, vol. 16, no. 6 A, pp. 3299-3306.
Tímár, J. ; Rásó, E. ; Fazakas, Zs ; Silletti, S. ; Raz, A. ; Honn, K. V. / Multiple use of a signal transduction pathway in tumor cell invasion. In: Anticancer Research. 1996 ; Vol. 16, No. 6 A. pp. 3299-3306.
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