Multiple tumor case: Report and analysis of an autopsy case

T. Tornóczky, Károly Szuhai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An interesting multiple tumor case is described in which 4 different kinds of tumors were diagnosed in the same patient at autopsy and histopathologic examination. The tumors were the following: 1) inoma of the anterior pituitary lobe; 2) basal cell carcinoma of the nose; 3) adenocarcinoma of the colon sigmoideum; 4) multiple oncocytomas (oncocytomatosis) in the kidneys. Immunohistochemical investigation for p53 revealed a strong intranuclear positivity in the colonic carcinoma cells as a result of the overexpression of a possible mutant type of the protein. The other 3 tumors were negative with the p53-specific DO-7 antibody, therefore, no point mutation was thought to be present in the p53 gene of the tumor cells. The immunohistochemical and anamnestic data suggested that this is not a hereditary syndrome, and there is no common pathogenesis of these tumors. Its rarity is interesting in our case because of the coincidence of 4 different unrelated tumors and the absence of anamnestic data for familial accumulation or predisposition for multiple tumors.

Original languageEnglish
Pages (from-to)715-717
Number of pages3
JournalTumori
Volume83
Issue number3
Publication statusPublished - May 1997

Fingerprint

Autopsy
Neoplasms
Anterior Pituitary Gland
Basal Cell Carcinoma
p53 Genes
Mutant Proteins
Nose
Point Mutation
Colon
Adenocarcinoma
Carcinoma
Kidney
Antibodies

Keywords

  • basal cell carcinoma
  • colon cancer
  • multiple tumor syndrome
  • oncocytoma
  • p53 prolactinoma

ASJC Scopus subject areas

  • Cancer Research

Cite this

Multiple tumor case : Report and analysis of an autopsy case. / Tornóczky, T.; Szuhai, Károly.

In: Tumori, Vol. 83, No. 3, 05.1997, p. 715-717.

Research output: Contribution to journalArticle

Tornóczky, T & Szuhai, K 1997, 'Multiple tumor case: Report and analysis of an autopsy case', Tumori, vol. 83, no. 3, pp. 715-717.
Tornóczky, T. ; Szuhai, Károly. / Multiple tumor case : Report and analysis of an autopsy case. In: Tumori. 1997 ; Vol. 83, No. 3. pp. 715-717.
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