Multiszisztémás atrophia: uj korszak kezdete a neurodegeneratív betegségek történetében.

Translated title of the contribution: Multiple system atrophy: the beginning of a new era in the history of neurodegenerative diseases

Mátyás Papp, T. Kovács

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Multiple system atrophy (MSA) belongs to the neurodegenerative diseases of the nervous system, but it is different from them in many aspects: it has no familiar form and no genetic factor was identified in the pathomechanism. Its neuropathology is unique too, because oligodendroglial cells are harbouring the main pathological burden. It was described in MSA that there is no elective neuronal degeneration in neurodegenerative disorders: the glial cells show the same pathochemical and structural abnormalities as found in the neurones. The discovery of the glial cytoplasmic inclusions, as a pathognostic marker for MSA, has directed attention to the glial cells in other neurodegenerative disorders. As a result of this, there are several neurodegenerative diseases nowadays in which glial inclusions were described, similar to the neuronal inclusions in their structural and biochemical properties and some of them became the diagnostic marker of the disease. In our review we summarize the clinical features, the history and the neuropathology of MSA and we discuss its special features.

Original languageHungarian
Pages (from-to)308-320
Number of pages13
JournalIdeggyógyászati szemle
Volume59
Issue number9-10
Publication statusPublished - Sep 20 2006

Fingerprint

Multiple System Atrophy
Neuroglia
Neurodegenerative Diseases
History
Inclusion Bodies
Nervous System
Neurons
Neuropathology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Multiszisztémás atrophia : uj korszak kezdete a neurodegeneratív betegségek történetében. / Papp, Mátyás; Kovács, T.

In: Ideggyógyászati szemle, Vol. 59, No. 9-10, 20.09.2006, p. 308-320.

Research output: Contribution to journalArticle

@article{3e451804abc942c98067507b7b5f1968,
title = "Multisziszt{\'e}m{\'a}s atrophia: uj korszak kezdete a neurodegenerat{\'i}v betegs{\'e}gek t{\"o}rt{\'e}net{\'e}ben.",
abstract = "Multiple system atrophy (MSA) belongs to the neurodegenerative diseases of the nervous system, but it is different from them in many aspects: it has no familiar form and no genetic factor was identified in the pathomechanism. Its neuropathology is unique too, because oligodendroglial cells are harbouring the main pathological burden. It was described in MSA that there is no elective neuronal degeneration in neurodegenerative disorders: the glial cells show the same pathochemical and structural abnormalities as found in the neurones. The discovery of the glial cytoplasmic inclusions, as a pathognostic marker for MSA, has directed attention to the glial cells in other neurodegenerative disorders. As a result of this, there are several neurodegenerative diseases nowadays in which glial inclusions were described, similar to the neuronal inclusions in their structural and biochemical properties and some of them became the diagnostic marker of the disease. In our review we summarize the clinical features, the history and the neuropathology of MSA and we discuss its special features.",
author = "M{\'a}ty{\'a}s Papp and T. Kov{\'a}cs",
year = "2006",
month = "9",
day = "20",
language = "Hungarian",
volume = "59",
pages = "308--320",
journal = "Ideggyogyaszati Szemle",
issn = "0019-1442",
publisher = "Ifjusagi Lap-es Konyvkiado Vallalat",
number = "9-10",

}

TY - JOUR

T1 - Multiszisztémás atrophia

T2 - uj korszak kezdete a neurodegeneratív betegségek történetében.

AU - Papp, Mátyás

AU - Kovács, T.

PY - 2006/9/20

Y1 - 2006/9/20

N2 - Multiple system atrophy (MSA) belongs to the neurodegenerative diseases of the nervous system, but it is different from them in many aspects: it has no familiar form and no genetic factor was identified in the pathomechanism. Its neuropathology is unique too, because oligodendroglial cells are harbouring the main pathological burden. It was described in MSA that there is no elective neuronal degeneration in neurodegenerative disorders: the glial cells show the same pathochemical and structural abnormalities as found in the neurones. The discovery of the glial cytoplasmic inclusions, as a pathognostic marker for MSA, has directed attention to the glial cells in other neurodegenerative disorders. As a result of this, there are several neurodegenerative diseases nowadays in which glial inclusions were described, similar to the neuronal inclusions in their structural and biochemical properties and some of them became the diagnostic marker of the disease. In our review we summarize the clinical features, the history and the neuropathology of MSA and we discuss its special features.

AB - Multiple system atrophy (MSA) belongs to the neurodegenerative diseases of the nervous system, but it is different from them in many aspects: it has no familiar form and no genetic factor was identified in the pathomechanism. Its neuropathology is unique too, because oligodendroglial cells are harbouring the main pathological burden. It was described in MSA that there is no elective neuronal degeneration in neurodegenerative disorders: the glial cells show the same pathochemical and structural abnormalities as found in the neurones. The discovery of the glial cytoplasmic inclusions, as a pathognostic marker for MSA, has directed attention to the glial cells in other neurodegenerative disorders. As a result of this, there are several neurodegenerative diseases nowadays in which glial inclusions were described, similar to the neuronal inclusions in their structural and biochemical properties and some of them became the diagnostic marker of the disease. In our review we summarize the clinical features, the history and the neuropathology of MSA and we discuss its special features.

UR - http://www.scopus.com/inward/record.url?scp=39049191188&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39049191188&partnerID=8YFLogxK

M3 - Article

C2 - 17165375

AN - SCOPUS:39049191188

VL - 59

SP - 308

EP - 320

JO - Ideggyogyaszati Szemle

JF - Ideggyogyaszati Szemle

SN - 0019-1442

IS - 9-10

ER -