Multiple sclerosis: Magnetization transfer histogram analysis of segmented normal-appearing white matter

Isabelle Catalaa, Robert I. Grossman, Dennis L. Kolson, Jayaram K. Udupa, L. Nyúl, Luogang Wei, Xuan Zhang, Marcia Polansky, Lois J. Mannon, Joseph C. McGowan

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

PURPOSE: To investigate and characterize the global distribution of magnetization transfer (MT) ratio values of normal-appearing white matter (NAWM) in patients with relapsing-remitting multiple sclerosis (MS) and test the hypothesis that the MT histogram for NAWM reflects disease progression. MATERIALS AND METHODS: Conventional and MT magnetic resonance (MR) images were obtained in 23 patients and 25 healthy volunteers. Clinical tests for comparison with the MT histogram parameters included the Extended Disability Status Scale and the ambulation index. Lesion load calculated with T2- weighted MR images and whole-brain and white matter volumes were measured. RESULTS: The location of the MT histogram peak and the mean MT ratio for NAWM were significantly lower in patients with MS than in control subjects. In longitudinal studies, the histogram peak location and mean MT ratio shifted in the direction of normal values as the duration of disease increased. A mean of 26.5% of the volume of new lesions identified on the later studies were demonstrated to have originated in NAWM corresponding to 'lost' pixels on the histogram. CONCLUSION: MT histogram analysis of NAWM, including longitudinal analysis, may provide new prognostic information regarding lesion formation and increase understanding of the course of the disease.

Original languageEnglish
Pages (from-to)351-355
Number of pages5
JournalRadiology
Volume216
Issue number2
Publication statusPublished - Aug 2000

Fingerprint

Multiple Sclerosis
Reference Values
Magnetic Resonance Spectroscopy
Leukoencephalopathies
Relapsing-Remitting Multiple Sclerosis
Walking
Longitudinal Studies
Disease Progression
Healthy Volunteers
White Matter
Brain

Keywords

  • Brain, MR
  • Brain, white matter
  • Magnetic resonance (MR), magnetization transfer
  • Sclerosis, multiple

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Catalaa, I., Grossman, R. I., Kolson, D. L., Udupa, J. K., Nyúl, L., Wei, L., ... McGowan, J. C. (2000). Multiple sclerosis: Magnetization transfer histogram analysis of segmented normal-appearing white matter. Radiology, 216(2), 351-355.

Multiple sclerosis : Magnetization transfer histogram analysis of segmented normal-appearing white matter. / Catalaa, Isabelle; Grossman, Robert I.; Kolson, Dennis L.; Udupa, Jayaram K.; Nyúl, L.; Wei, Luogang; Zhang, Xuan; Polansky, Marcia; Mannon, Lois J.; McGowan, Joseph C.

In: Radiology, Vol. 216, No. 2, 08.2000, p. 351-355.

Research output: Contribution to journalArticle

Catalaa, I, Grossman, RI, Kolson, DL, Udupa, JK, Nyúl, L, Wei, L, Zhang, X, Polansky, M, Mannon, LJ & McGowan, JC 2000, 'Multiple sclerosis: Magnetization transfer histogram analysis of segmented normal-appearing white matter', Radiology, vol. 216, no. 2, pp. 351-355.
Catalaa I, Grossman RI, Kolson DL, Udupa JK, Nyúl L, Wei L et al. Multiple sclerosis: Magnetization transfer histogram analysis of segmented normal-appearing white matter. Radiology. 2000 Aug;216(2):351-355.
Catalaa, Isabelle ; Grossman, Robert I. ; Kolson, Dennis L. ; Udupa, Jayaram K. ; Nyúl, L. ; Wei, Luogang ; Zhang, Xuan ; Polansky, Marcia ; Mannon, Lois J. ; McGowan, Joseph C. / Multiple sclerosis : Magnetization transfer histogram analysis of segmented normal-appearing white matter. In: Radiology. 2000 ; Vol. 216, No. 2. pp. 351-355.
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abstract = "PURPOSE: To investigate and characterize the global distribution of magnetization transfer (MT) ratio values of normal-appearing white matter (NAWM) in patients with relapsing-remitting multiple sclerosis (MS) and test the hypothesis that the MT histogram for NAWM reflects disease progression. MATERIALS AND METHODS: Conventional and MT magnetic resonance (MR) images were obtained in 23 patients and 25 healthy volunteers. Clinical tests for comparison with the MT histogram parameters included the Extended Disability Status Scale and the ambulation index. Lesion load calculated with T2- weighted MR images and whole-brain and white matter volumes were measured. RESULTS: The location of the MT histogram peak and the mean MT ratio for NAWM were significantly lower in patients with MS than in control subjects. In longitudinal studies, the histogram peak location and mean MT ratio shifted in the direction of normal values as the duration of disease increased. A mean of 26.5{\%} of the volume of new lesions identified on the later studies were demonstrated to have originated in NAWM corresponding to 'lost' pixels on the histogram. CONCLUSION: MT histogram analysis of NAWM, including longitudinal analysis, may provide new prognostic information regarding lesion formation and increase understanding of the course of the disease.",
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