Multiple nitric oxide sources in neurogenic plasma extravasation in rat hindpaw skin

Margit Szikszay, Sándor Bartos, Gyöngyi Horváth, György Benedek

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6 Citations (Scopus)


The contribution of nitric oxide (NO) to capsaicin-evoked plasma extravasation was studied in rat hindpaw skin. Two inhibitors of NO synthase were used: 7-nitroindazole, with a selectivity for nerve-derived NO, and the L-arginine derivative, Nω-nitro-L-arginine (L-NOARG), which is a non- selective inhibitor. Plasma extravasation was induced by intraplantar injection of 5 μg/50 μl capsaicin and measured by the Evans blue leakage technique. Both acute and chronic administration of 7-nitroindazole significantly reduced capsaicin-evoked plasma extravasation in rat hind-paw skin, whereas L-NOARG enhanced it. This enhancement was abolished non- stereospecifically by either L- or D-arginine. Our results suggest that NO production from different sources yields a complex action in maintaining the endothelial integrity in neurogenic plasma extravasation.

Original languageEnglish
Pages (from-to)1119-1125
Number of pages7
JournalLife Sciences
Issue number13
Publication statusPublished - Aug 21 1998



  • 7-nitroindazole
  • Capsaicin
  • Inflammation
  • Nω-nitro-L-arginine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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