Multiple modes of operation of cardiac autonomic control: development of the ideas from Cannon and Brooks to the present

Kiyomi Koizumi, Mark Kollai

Research output: Contribution to journalArticle

32 Citations (Scopus)


Since Cannon's time much emphasis has been placed on reciprocal control of the organ function by the autonomic nerves while other modes of control has been neglected. In our laboratory, prompted by Dr. Brooks, we initiated the study of the autonomic control of the heart by recording simultaneously the activity of cardiac sympathetic and parasympathetic nerves under a variety of conditions in chloralose anesthetized dogs. We have demonstrated that the central nervous system exercises reciprocal as well as non-reciprocal pattern of control over the two arms of the autonomic outflows under different physiological and behavioral conditions, and that each mode of control has an important functional significance.

Original languageEnglish
Pages (from-to)19-29
Number of pages11
JournalJournal of the Autonomic Nervous System
Issue number1-2
Publication statusPublished - Nov 1992



  • Autonomic control
  • Cardiac sympathetic nerve
  • Cardiac vagus nerve
  • Non-reciprocal control
  • Reciprocal control

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Clinical Neurology

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