Multiple functional attributes of glucose-monitoring neurons in the medial orbitofrontal (ventrolateral prefrontal) cortex

István Szabó, Edina Hormay, Bettina Csetényi, Bernadett Nagy, L. Lénárd, Zoltán Karádi

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Multiple functional attributes of glucose-monitoring neurons in the medial orbitofrontal (ventrolateral prefrontal) cortex. NEUROSCI BIOBEHAV REV 73(1) XXX-XXX, 2017.- Special chemosensory cells, the glucose-monitoring (GM) neurons, reportedly involved in the central feeding control, exist in the medial orbitofrontal (ventrolateral prefrontal) cortex (mVLPFC). Electrophysiological, metabolic and behavioral studies reveal complex functional attributes of these cells and raise their homeostatic significance. Single neuron recordings, by means of the multibarreled microelectrophoretic technique, elucidate differential sensitivities of limbic forebrain neurons in the rat and the rhesus monkey to glucose and other chemicals, whereas gustatory stimulations demonstrate their distinct taste responsiveness. Metabolic examinations provide evidence for alteration of blood glucose level in glucose tolerance test and elevation of plasma triglyceride concentration after destruction of the local GM cells by streptozotocin (STZ). In behavioral studies, STZ microinjection into the mVLPFC fails to interfere with the acquisition of saccharin conditioned taste avoidance, does cause, however, taste perception deficit in taste reactivity tests. Multiple functional attributes of GM neurons in the mVLPFC, within the frame of the hierarchically organized central GM neuronal network, appear to play important role in the maintenance of the homeostatic balance.

Original languageEnglish
Pages (from-to)44-53
Number of pages10
JournalNeuroscience and Biobehavioral Reviews
Volume85
DOIs
Publication statusPublished - Feb 1 2018

Fingerprint

Prefrontal Cortex
Neurons
Glucose
Streptozocin
Taste Perception
Saccharin
Microinjections
Glucose Tolerance Test
Prosencephalon
Macaca mulatta
Blood Glucose
Triglycerides
Maintenance

Keywords

  • Electrophysiological recordings
  • Glucose-monitoring neurons
  • Limbic forebrain
  • Medial orbitofrontal (ventrolateral prefrontal) cortex
  • Metabolic and behavioral alterations

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Multiple functional attributes of glucose-monitoring neurons in the medial orbitofrontal (ventrolateral prefrontal) cortex. / Szabó, István; Hormay, Edina; Csetényi, Bettina; Nagy, Bernadett; Lénárd, L.; Karádi, Zoltán.

In: Neuroscience and Biobehavioral Reviews, Vol. 85, 01.02.2018, p. 44-53.

Research output: Contribution to journalReview article

Szabó, István ; Hormay, Edina ; Csetényi, Bettina ; Nagy, Bernadett ; Lénárd, L. ; Karádi, Zoltán. / Multiple functional attributes of glucose-monitoring neurons in the medial orbitofrontal (ventrolateral prefrontal) cortex. In: Neuroscience and Biobehavioral Reviews. 2018 ; Vol. 85. pp. 44-53.
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