Multiplex endokrin neoplasia típusú medullaris pajzsmirigy-carcinoma egy család három generációjában.

Translated title of the contribution: Multiple endocrine neoplasia-type medullary thyroid carcinoma in three generations of a family

N. Z. Takácsi, I. Poller, L. Trón, G. Dabasi, G. Rákóczy, M. Füzy, Z. Szentirmay, O. Esik

Research output: Contribution to journalReview article

Abstract

The familial accumulation of a multiple endocrine neoplasia (MEN) type 2a medullary thyroid carcinoma, is described based on the retrospective analysis of a family history. The proband was characterized by medullary carcinoma (MC) combined with phaeochromocytoma, her child had been shown to suffer from MC. In the third generation of the family C-cell hyperplasia and bilateral adrenal hyperplasia occurred. It is shown that in order to arrive at a correct decision as regards the therapy to be used, modern laboratory tests (serum calcitonin, CEA-analysis) and diagnostic imaging methods (ultrasound, computer tomography, magnetic resonance imaging, positron emission tomography, metaiodobenzylguanidine scintigraphy) should be used. It is emphasized that the available therapeutic means (surgery, radiotherapy, nuclear medicine) have to be carefully selected and, if necessary, combined. In medullary thyroid carcinoma associated tumours in other endocrine organs should be expected to occur. Family screening using blood chemical and genetic tests are recommended in asymptomatic cases, since their surgical treatment can in this way lead to complete recovery.

Original languageHungarian
Pages (from-to)2883-2888
Number of pages6
JournalOrvosi hetilap
Volume139
Issue number48
Publication statusPublished - Nov 29 1998

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this