Multifaceted plasma membrane Ca2+ pumps: From structure to intracellular Ca2+ handling and cancer

Rita Padányi, Katalin Pászty, Luca Hegedus, Karolina Varga, Béla Papp, John T. Penniston, Ágnes Enyedi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Plasma membrane Ca2+ ATPases (PMCAs) are intimately involved in the control of intracellular Ca2+ concentration. They reduce Ca2+ in the cytosol not only by direct ejection, but also by controlling the formation of inositol-1,4,5-trisphosphate and decreasing Ca2+ release from the endoplasmic reticulum Ca2+ pool. In mammals four genes (PMCA1-4) are expressed, and alternative RNA splicing generates more than twenty variants. The variants differ in their regulatory characteristics. They localize into highly specialized membrane compartments and respond to the incoming Ca2+ with distinct temporal resolution. The expression pattern of variants depends on cell type; a change in this pattern can result in perturbed Ca2+ homeostasis and thus altered cell function. Indeed, PMCAs undergo remarkable changes in their expression pattern during tumorigenesis that might significantly contribute to the unbalanced Ca2+ homeostasis of cancer cells. This article is part of a Special Issue entitled: Calcium and Cell Fate Guest Editors: Jacques Haiech, Claus Heizmann, Joachim Krebs, Thierry Capiod and Olivier Mignen.

Original languageEnglish
Pages (from-to)1351-1363
Number of pages13
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1863
Issue number6
DOIs
Publication statusPublished - Jun 1 2016

Keywords

  • Ca signaling
  • Ca-calmodulin
  • Differentiation
  • Phosphatidylinositol-4,5-bisphosphate binding
  • Plasma membrane Ca ATPase
  • Tumor progression

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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