Multidrug resistance through the spectacle of P-glycoprotein

K. Goda, Z. Bacsó, Gábor Szabó

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

P-glycoprotein (Pgp), coded for by the mdr1 gene, is one of the ABC transporters held responsible for the phenomenon of multidrug resistance (mdr), which is reflected by a rapidly escalating failure of chemotherapy with different classes of cytotoxic agents: anthracyclins, vinca alkaloids, taxanes, epipodophylotoxins. Although overcoming resistance conveyed by Pgp alone may not be sufficient for reaching effective treatment, the abundance of observations available for this paradigmatic multidrug transporter at both in vitro and in vivo setting is a tempting ground for an updated assessment of the main currents of mdr research. In this review we attempt to help keep track of the features of Pgp-mediated drug transport that serve as the major starting points for ongoing efforts of mdr reversal. We will analyze the slowly narrowing gaps that prevail between our ever increasing understanding at the protein, cell and organism level, focusing on the molecular interactions involving Pgp.

Original languageEnglish
Pages (from-to)281-297
Number of pages17
JournalCurrent Cancer Drug Targets
Volume9
Issue number3
DOIs
Publication statusPublished - May 2009

Fingerprint

Multiple Drug Resistance
P-Glycoprotein
Vinca Alkaloids
Taxoids
ATP-Binding Cassette Transporters
Cytotoxins
Drug Therapy
Research
Pharmaceutical Preparations
Genes
Proteins
Therapeutics

Keywords

  • Hydrophobicity
  • Membrane microdomains
  • Multidrug resistance
  • P-glycoprotein

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Cancer Research

Cite this

Multidrug resistance through the spectacle of P-glycoprotein. / Goda, K.; Bacsó, Z.; Szabó, Gábor.

In: Current Cancer Drug Targets, Vol. 9, No. 3, 05.2009, p. 281-297.

Research output: Contribution to journalArticle

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