Multidrug resistance reversal by 3-formylchromones in human colon concer and human mdr1 gene-transfected mouse lymphoma cells

Zoltán Baráth, Rita Radics, G. Spengler, I. Ocsovszki, Masami Kawase, Noboru Motohashi, Yoshiaki Shirataki, Anamik Shah, J. Molnár

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Several new 3-formylchromone derivatives proved to be modifiers of multidrug resistance in mouse lymphoma cells and in human Colo320 colon cancer cells. There is apparently a structure-activity relationship between the antiproliferative multidrug resistance-reversing effect and the chemical structure of the 3-formylchromones. The total polar surface areas and the ground state dipole moments of the molecules are presumed to play a key role in the multidrug resistance-reversing effect. The log P values can provide an adequate explanation for the selective cytotoxicity against cancer cells.

Original languageEnglish
Pages (from-to)645-650
Number of pages6
JournalIn Vivo
Volume20
Issue number5
Publication statusPublished - Sep 2006

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Multiple Drug Resistance
Lymphoma
Colon
Genes
Cells
Dipole moment
Cytotoxicity
Ground state
Structure-Activity Relationship
Derivatives
Colonic Neoplasms
Molecules
formylchromone
Neoplasms

Keywords

  • Formylchromones
  • Multidrug resistance-reversing effect

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Multidrug resistance reversal by 3-formylchromones in human colon concer and human mdr1 gene-transfected mouse lymphoma cells. / Baráth, Zoltán; Radics, Rita; Spengler, G.; Ocsovszki, I.; Kawase, Masami; Motohashi, Noboru; Shirataki, Yoshiaki; Shah, Anamik; Molnár, J.

In: In Vivo, Vol. 20, No. 5, 09.2006, p. 645-650.

Research output: Contribution to journalArticle

Baráth, Zoltán ; Radics, Rita ; Spengler, G. ; Ocsovszki, I. ; Kawase, Masami ; Motohashi, Noboru ; Shirataki, Yoshiaki ; Shah, Anamik ; Molnár, J. / Multidrug resistance reversal by 3-formylchromones in human colon concer and human mdr1 gene-transfected mouse lymphoma cells. In: In Vivo. 2006 ; Vol. 20, No. 5. pp. 645-650.
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