Multicentric plasmocytic Castleman's disease with polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome and coexistent human herpes virus-6 infection -A possible relationship

Ád́m Fazakas, Márta Csire, G. Berencsi, Ágota Szepesi, A. Matolcsy, Lajos Jakab, I. Karádi, J. Várkonyi

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9 Citations (Scopus)

Abstract

Authors report a case of Castleman's disease (CD) with polyneuropathy, organomegaly, endocrinopathy, M protein, skin change (POEMS) syndrome. According to the present knowledge, these two rare conditions are often induced by Human Herpes Vrus-8 (HHV-8) or by Human Immunodefeciency Virus, separately or in combination. In this case, however, HHV-6 viral DNA had been detected in the blood and lymph node samples by PCR. The authors conclude that the modulation of immune functions by HHV-6 might be responsible for the development of CD and POEMS syndrome in the referred case.

Original languageEnglish
Pages (from-to)1661-1665
Number of pages5
JournalLeukemia and Lymphoma
Volume50
Issue number10
DOIs
Publication statusPublished - 2009

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POEMS Syndrome
Giant Lymph Node Hyperplasia
Human Herpesvirus 6
Virus Diseases
Viral DNA
Lymph Nodes
Viruses
Polymerase Chain Reaction
Multi-centric Castleman's Disease

Keywords

  • Castleman's disease
  • HHV-6
  • POEMS syndrome

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

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title = "Multicentric plasmocytic Castleman's disease with polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome and coexistent human herpes virus-6 infection -A possible relationship",
abstract = "Authors report a case of Castleman's disease (CD) with polyneuropathy, organomegaly, endocrinopathy, M protein, skin change (POEMS) syndrome. According to the present knowledge, these two rare conditions are often induced by Human Herpes Vrus-8 (HHV-8) or by Human Immunodefeciency Virus, separately or in combination. In this case, however, HHV-6 viral DNA had been detected in the blood and lymph node samples by PCR. The authors conclude that the modulation of immune functions by HHV-6 might be responsible for the development of CD and POEMS syndrome in the referred case.",
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T1 - Multicentric plasmocytic Castleman's disease with polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome and coexistent human herpes virus-6 infection -A possible relationship

AU - Fazakas, Ád́m

AU - Csire, Márta

AU - Berencsi, G.

AU - Szepesi, Ágota

AU - Matolcsy, A.

AU - Jakab, Lajos

AU - Karádi, I.

AU - Várkonyi, J.

PY - 2009

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N2 - Authors report a case of Castleman's disease (CD) with polyneuropathy, organomegaly, endocrinopathy, M protein, skin change (POEMS) syndrome. According to the present knowledge, these two rare conditions are often induced by Human Herpes Vrus-8 (HHV-8) or by Human Immunodefeciency Virus, separately or in combination. In this case, however, HHV-6 viral DNA had been detected in the blood and lymph node samples by PCR. The authors conclude that the modulation of immune functions by HHV-6 might be responsible for the development of CD and POEMS syndrome in the referred case.

AB - Authors report a case of Castleman's disease (CD) with polyneuropathy, organomegaly, endocrinopathy, M protein, skin change (POEMS) syndrome. According to the present knowledge, these two rare conditions are often induced by Human Herpes Vrus-8 (HHV-8) or by Human Immunodefeciency Virus, separately or in combination. In this case, however, HHV-6 viral DNA had been detected in the blood and lymph node samples by PCR. The authors conclude that the modulation of immune functions by HHV-6 might be responsible for the development of CD and POEMS syndrome in the referred case.

KW - Castleman's disease

KW - HHV-6

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