Multicentric plasmocytic Castleman's disease with polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome and coexistent human herpes virus-6 infection -A possible relationship

Ád́m Fazakas, Márta Csire, György Berencsi, Ágota Szepesi, András Matolcsy, Lajos Jakab, István Karádi, Judit Várkonyi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Authors report a case of Castleman's disease (CD) with polyneuropathy, organomegaly, endocrinopathy, M protein, skin change (POEMS) syndrome. According to the present knowledge, these two rare conditions are often induced by Human Herpes Vrus-8 (HHV-8) or by Human Immunodefeciency Virus, separately or in combination. In this case, however, HHV-6 viral DNA had been detected in the blood and lymph node samples by PCR. The authors conclude that the modulation of immune functions by HHV-6 might be responsible for the development of CD and POEMS syndrome in the referred case.

Original languageEnglish
Pages (from-to)1661-1665
Number of pages5
JournalLeukemia and Lymphoma
Volume50
Issue number10
DOIs
Publication statusPublished - Nov 11 2009

Keywords

  • Castleman's disease
  • HHV-6
  • POEMS syndrome

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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