Multicentre study of fragrance allergy in Hungary: Immediate and late type reactions

Erzsébet Temesvári, Ilona Németh, Mátyás J. Baló-Banga, Sándor Husz, Valéria Kohánka, Zsuzsa Somos, Rita Judák, É V.A. Remenyik, Andrea Szegedi, László Nebenführer, Csilla Mészáros, Attila Horváth

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23 Citations (Scopus)


The authors followed the frequency of fragrance contact sensitization in Hungary in a multicentre study in the years 1998 and 1999. A total of 3604 patients were tested with fragrance mix (FM), and positive reactions were observed in 294 (8.2%). In 160 FM hypersensitive patients, the study was continued with patch testing of the mix constituents (cinnamic alcohol, cinnamic aldehyde, eugenol, amyl cinnamic aldehyde, hydroxycitronellal, geraniol, isoeugenol, oak moss absolute). Of the patients tested, 70.6% produced positive reactions to the constituents. FM contact sensitization was mainly observed in female patients (74.4%). The incidence of contact urticaria in FM hypersensitive patients was 6.1%. Simultaneous patch test trials of other environmental contact allergens, in both early and late evaluations, mainly confirmed hypersensitivity reactions to balsams. Female dominance of hypersensitivity reactions observed during testing the individual components of the mix was striking (82.4%). In positive skin reactions, cinnamic alcohol, isoeugenol and oak moss provoked skin symptoms most frequently. We also tested the 104 patients who produced negative reactions to FM with the constituent individual allergens, with 11.9% positive incidence. The clinical symptoms of the patients were above all manifest in the form of contact eczema, located on the hands, face, eyelids and axillae. With this study, the authors, members of the Hungarian Contact Dermatitis Research Group, call attention to one of the most frequent allergens in the environment.

Original languageEnglish
Pages (from-to)325-330
Number of pages6
JournalContact Dermatitis
Issue number6
Publication statusPublished - Jun 2002



  • Associated contact sensitization
  • Constituent allergens
  • Contact sensitization
  • Fragrance mix

ASJC Scopus subject areas

  • Immunology and Allergy
  • Dermatology

Cite this

Temesvári, E., Németh, I., Baló-Banga, M. J., Husz, S., Kohánka, V., Somos, Z., Judák, R., Remenyik, É. V. A., Szegedi, A., Nebenführer, L., Mészáros, C., & Horváth, A. (2002). Multicentre study of fragrance allergy in Hungary: Immediate and late type reactions. Contact Dermatitis, 46(6), 325-330.