Multi-endpoint biological monitoring in combined, carcinogenic occupational exposures

Katalin Szendi, László Hornyák, C. Varga

Research output: Contribution to journalArticle

Abstract

We aimed to develop a relevant multi-endpoint biomonitoring system by studying different genotoxicity biomarkers in complex carcinogenic exposures under occupational situations. Altogether 109 workers were followed in five different workplaces. The combined carcinogenic exposures were monitored in the urine and peripheral blood samples using Ames mutagenicity test and cytogenetic analyzes. The different genotoxicity endpoints studied showed different results in the same carcinogenic exposure situations. The urinary mutagenicity tests provided more information and proved to be more sensitive compared to the cytogenetic tests in the majority of cases. In complex exposures multistep biomonitoring panel should be applied, because the exact mechanisms of the combination of single exposing agents are not known. Such a panel should involve monitoring different endpoints, e.g. point mutations, chromosomal mutations. A relatively affordable and rapid testing panel was developed using validated tests as Ames and cytogenetic assays, but its practical use should be confirmed by further investigations.

Original languageEnglish
Pages (from-to)323-331
Number of pages9
JournalInternational Journal of Environmental Health Research
Volume27
Issue number5
DOIs
Publication statusPublished - Sep 3 2017

Fingerprint

Mutagenicity Tests
Environmental Monitoring
Biomarkers
Occupational Exposure
Cytogenetics
Assays
Blood
Monitoring
Cytogenetic Analysis
Testing
Point Mutation
Workplace
Urine
Mutation

Keywords

  • biological monitoring
  • carcinogenic occupational exposure
  • cytogenetics
  • Genotoxicity

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Multi-endpoint biological monitoring in combined, carcinogenic occupational exposures. / Szendi, Katalin; Hornyák, László; Varga, C.

In: International Journal of Environmental Health Research, Vol. 27, No. 5, 03.09.2017, p. 323-331.

Research output: Contribution to journalArticle

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