Mucocutaneous Candidiasis

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Candida species are major causes of invasive and mucocutaneous infections. Invasive candidiasis may involve any internal organ or anatomic site, and is a significant cause of morbidity and mortality in immunocompromised individuals. Candida may also cause a broad range of mucocutaneous infections. Although healthy individuals carry Candida on body surfaces, only a few suffer from overt mucocutaneous candidiasis (MC) characterized by local signs of infection and visible, creamy-white curd-like patches on mucosal surfaces. Various recognition pathways and effector mechanisms are involved in triggering innate and adaptive host immune responses to Candida. Primary immunodeficiency disorders (PIDs) affecting the phagocytic cells predispose patients to invasive candidiasis. PIDs characterized by an impairment of IL-17 T cell-mediated immunity confer predisposition to MC, with Candida albicans in particular. We describe here clinical features of MC and discuss inborn errors of immunity leading to impaired IL-17-mediated defense and chronic MC.

Original languageEnglish
Title of host publicationStiehm's Immune Deficiencies
PublisherElsevier Inc.
Pages775-802
Number of pages28
ISBN (Electronic)9780124058606
ISBN (Print)9780124055469
DOIs
Publication statusPublished - Aug 12 2014

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Keywords

  • Candida
  • IL-17 T cell-mediated immunity
  • Mucocutaneous candidiasis
  • Primary immunodeficiency disorders

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Maródi, L. (2014). Mucocutaneous Candidiasis. In Stiehm's Immune Deficiencies (pp. 775-802). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-405546-9.00040-6