MSC, a new benzoquinone-containing natural product with antimetastatic effect

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) has been invented by Hungarian chemists under the trade name of AVEMAR Oral administration (3g/leg body weight) of MSC enhances blastic transformation of splenic lymphocytes in mice. The same treatment shortens the survival time of skin grafts in a co-isogenic mouse skin transplantation model, pointing to the immune-reconstructive effect of MSC. A highly significant antimetastatic effect of MSC has been observed in three metastasis models (3LL-HH, B16, HCR-25). The antimetastatic effect of MSC - besides the immune-reconstitution - may also be due to its cell adhesion inhibitory, cell proliferation inhibitory, apoptosis enhancing, and antioxidant characteristics, also observed in our in vitro experiments. It is even more noteworthy that combined treatment with MSC and one of the following antineoplastic agents (5-FU and DTIC) - both in wide use in every clay clinical practice - exhibited a significantly enhanced antimetastatic effect in appropriate metastasis models (established from C38 mouse colon carcinoma and B16 mouse melanoma respectively) as compared to the effect elicited by any component of these therapeutic compositions (MSC + 5-FU and MSC + DTIC) administered alone. The results show that the fermented wheat germ extract (MSC) has more than an additive effect and synergistically enhanced the metastasis inhibitory effect of both antineoplastic agents studied till now. It is also worthy of mention that the synchronous treatment with MSC profoundly decreased the toxic side effects of the applied antineoplastic agents (decreased weight loss etc). Based on the biological effects of MSC - shown to be non-toxic by subacute toxicology studies - this product may be used as an adjuvant in the therapy of malignant neoplasia and other diseases caused by or following immune-deficiency.

Original languageEnglish
Pages (from-to)277-289
Number of pages13
JournalCancer Biotherapy and Radiopharmaceuticals
Volume14
Issue number4
DOIs
Publication statusPublished - Jan 1 1999

Keywords

  • AVEMAR
  • Combination chemotherapy
  • Fermented wheat germ extract
  • Immune- reconstruction
  • MSC
  • Metastasis-inhibition
  • Substituted benzoquinone

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology
  • Cancer Research

Fingerprint Dive into the research topics of 'MSC, a new benzoquinone-containing natural product with antimetastatic effect'. Together they form a unique fingerprint.

  • Cite this