MS and NMR investigation of bioactive quinazolones

Zoltán Szabó, E. Ősz, T. Lóránd

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To prepare effective PARP [poly(ADP)-ribose)polymerase-1] inhibitors, starting from 2-mercapto-4(3H)-quinazolone (1), several S-alkyl derivatives - 2-alkylsulfanyl-3H-quinazolin-4-ones (2-5, 7-9) - as well as an S-benzyl derivative (10) were prepared using a simple alkylation method. Some of them are known compounds. Their structure was studied thoroughly by MS and NMR methods.

Original languageEnglish
Pages (from-to)77-93
Number of pages17
JournalJournal of Biochemical and Biophysical Methods
Volume61
Issue number1-2 SPEC. ISS.
DOIs
Publication statusPublished - Oct 29 2004

Fingerprint

Nuclear magnetic resonance
Derivatives
Poly(ADP-ribose) Polymerases
Alkylation
4-hydroxyquinazoline
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerase Inhibitors

Keywords

  • Alkylation
  • MS spectroscopy
  • NMR spectroscopy
  • PARP inhibitor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Cite this

MS and NMR investigation of bioactive quinazolones. / Szabó, Zoltán; Ősz, E.; Lóránd, T.

In: Journal of Biochemical and Biophysical Methods, Vol. 61, No. 1-2 SPEC. ISS., 29.10.2004, p. 77-93.

Research output: Contribution to journalArticle

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