MS and NMR investigation of bioactive quinazolones

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3 Citations (Scopus)

Abstract

To prepare effective PARP [poly(ADP)-ribose)polymerase-1] inhibitors, starting from 2-mercapto-4(3H)-quinazolone (1), several S-alkyl derivatives - 2-alkylsulfanyl-3H-quinazolin-4-ones (2-5, 7-9) - as well as an S-benzyl derivative (10) were prepared using a simple alkylation method. Some of them are known compounds. Their structure was studied thoroughly by MS and NMR methods.

Original languageEnglish
Pages (from-to)77-93
Number of pages17
JournalJournal of biochemical and biophysical methods
Volume61
Issue number1-2 SPEC. ISS.
DOIs
Publication statusPublished - Oct 29 2004

Keywords

  • Alkylation
  • MS spectroscopy
  • NMR spectroscopy
  • PARP inhibitor

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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