MR imaging follow up after MR-guided focused ultrasound surgery for uterine leiomyomas - Early and mid term results

Csanád Várallyay, György Balázs, Zsuzsanna Lénárd, Viktor Bérczi, Zorán Belics, Gábor Bajzik, Paul Wragg, Kálmán Hüttl, Ferenc Jolesz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Rationale and Objectives: MR-guided Focused Ultrasound Surgery (MRgFUS) is an evolving thermoablative technique for treatment of benign and malignant soft tissue tumors. The feasibility and effectiveness of this non-invasive method has been tested by several investigators by treating uterine fibroid. The aim of the present study was to evaluate early and mid-term efficacy of MRgFUS treatment using MR imaging follow-ups. Materials and Methods: 38 patients with uterine fibroids were enrolled and treated by MRgFUS in a single center. MRI follow-up exams were performed 3 and 6 months after the procedure. Total fibroid volumes (FV) and non-perfused volumes (NPV) were compared and evaluated over time. Results: There was a significant reduction of FV at 3- and 6-month follow-ups (10±19%, p=0.022 and 19±29%, p<0.001, respectively). In the subgroup of fibroids smaller than 5.4 cm in diameter a 35±18% volume reduction was found after 6 months. There was also a positive correlation found between the early NPV and the FV decrease at 3- and 6-months follow-ups. Conclusion: This study suggests that MRgFUS can effectively coagulate uterine fibroid tissue. Smaller UFs can be most effectively treated within reasonable time with the used equipment.

Original languageEnglish
Pages (from-to)46-51
Number of pages6
JournalInterventional Medicine and Applied Science
Volume1
Issue number1
DOIs
Publication statusPublished - Dec 1 2009

Keywords

  • FUS
  • MR-guided Focused Ultrasound Surgery
  • uterine fibroid

ASJC Scopus subject areas

  • Medicine(all)

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