Moving to an A1C-based diagnosis of diabetes has a different impact on prevalence in different ethnic groups

Dirk L. Christensen, Daniel R. Witte, Lydia Kaduka, Marit E. Jørgensen, Knut Borch-Johnsen, Viswanathan Mohan, Jonathan E. Shaw, Adam G. Tab́ak, Dorte Vistisen

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125 Citations (Scopus)

Abstract

OBJECTIVE - To compare screen-detected diabetes prevalence and the degree of diagnostic agreement by ethnicity with the current oral glucose tolerance test (OGTT)-based and newly proposed A1C-based diagnostic criteria. RESEARCH DESIGN AND METHODS - Six studies (1999-2009) from Denmark, the U.K., Australia, Greenland, Kenya, and India were tested for the probability of an A1C ≥6.5% among diabetic case subjects based on an OGTT. The difference in probability between centers was analyzed by logistic regression adjusting for relevant confounders. RESULTS - Diabetes prevalence was lower with the A1C-based diagnostic criteria in four of six studies. The probability of an A1C ≥6.5% among OGTT-diagnosed case subjects ranged widely (17.0-78.0%) by study center. Differences in diagnostic agreement between ethnic subgroups in the U.K. study were of the same magnitude as between-country comparisons. CONCLUSIONS - A shift to an A1C-based diagnosis for diabetes will have substantially different consequences for diabetes prevalence across ethnic groups and populations.

Original languageEnglish
Pages (from-to)580-582
Number of pages3
JournalDiabetes care
Volume33
Issue number3
DOIs
Publication statusPublished - Mar 1 2010

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

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    Christensen, D. L., Witte, D. R., Kaduka, L., Jørgensen, M. E., Borch-Johnsen, K., Mohan, V., Shaw, J. E., Tab́ak, A. G., & Vistisen, D. (2010). Moving to an A1C-based diagnosis of diabetes has a different impact on prevalence in different ethnic groups. Diabetes care, 33(3), 580-582. https://doi.org/10.2337/dc09-1843