Moulting hormone regulates its receptor level in Drosophila melanogaster

Peter Deak, Peter Zavorszky, Peter Maroy

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22 Citations (Scopus)


The moulting hormone (MH) receptor level has been measured in embryonic first and third larval stages of D. melanogaster. Fluctuating receptor levels were found in all stages investigated with prominent peaks in 16 h embryos, 18 h first instar and 13 and 33 h third instar larvae. The receptor level peaks occur subsequent to MH peaks. Experimental 20-hydroxyecdysone feeding resulted in a rapid increase of the receptor level, which was dependent upon protein synthesis. When the conversion of ecdysone to 20-hydroxyecdysone was effectively inhibited by the drug, methyrapone, ecdysone was not effective in this receptor level augmentation. The receptor selectively binds 20-hydroxyecdysone only among the several ecdysteroids present in the embryo, providing further evidence that 20-hydroxyecdysone is the active hormone. The different efficacy of these steroids parallels the extent of receptor binding, suggesting the involvement of the receptor in its augmentation. The role of the receptor level in mediating the action of MH is discussed.

Original languageEnglish
Pages (from-to)847-852
Number of pages6
JournalInsect Biochemistry
Issue number8
Publication statusPublished - 1988


  • Drosophila melanogaster
  • moulting hormone receptor
  • receptor augmentation

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