Mortality of combined serum phosphorus and parathyroid hormone concentrations and their changes over time in hemodialysis patients

Elani Streja, Hsin Yi Wang, Wei Ling Lau, M. Molnár, Csaba P. Kovesdy, Kamyar Kalantar-Zadeh, Jongha Park

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Mineral and bone disorder (MBD) is common and associated with mortality in patients with chronic kidney disease (CKD) Given that disarrays in serum phosphorus (P) and parathyroid hormone (PTH) levels and their changes over time are closely interrelated, modeling mortality-predictability of their combinations may help improve CKD patient management. Methods: A historical cohort study was undertaken to evaluate the joint effect of serum P and PTH levels on mortality in 107,299 chronic hemodialysis (HD) patients. Changes in serum P and PTH levels over 6. months, in particular discordant changes, were also modeled with mortality. Results: HD patients were 64. ±. 15 (mean. ±. SD). years old and included 45% women, 33% African-American, and 59% diabetic. Compared with serum P level ≥. 7.0. mg/dL and PTH level ≥. 600. pg/mL, adjusted hazard ratio (HR) tended to be lowest in patients with serum P level of 3.5

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalBone
Volume61
DOIs
Publication statusPublished - Apr 2014

Fingerprint

Parathyroid Hormone
Phosphorus
Renal Dialysis
Mortality
Serum
Chronic Renal Insufficiency
Disease Management
African Americans
Minerals
Cohort Studies
Bone and Bones

Keywords

  • Bone
  • Hemodialysis
  • Hyperparathyroidism
  • Mineral
  • Phosphorus

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

Cite this

Mortality of combined serum phosphorus and parathyroid hormone concentrations and their changes over time in hemodialysis patients. / Streja, Elani; Wang, Hsin Yi; Lau, Wei Ling; Molnár, M.; Kovesdy, Csaba P.; Kalantar-Zadeh, Kamyar; Park, Jongha.

In: Bone, Vol. 61, 04.2014, p. 201-207.

Research output: Contribution to journalArticle

Streja, Elani ; Wang, Hsin Yi ; Lau, Wei Ling ; Molnár, M. ; Kovesdy, Csaba P. ; Kalantar-Zadeh, Kamyar ; Park, Jongha. / Mortality of combined serum phosphorus and parathyroid hormone concentrations and their changes over time in hemodialysis patients. In: Bone. 2014 ; Vol. 61. pp. 201-207.
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