Mortality in Hungarian patients with multiple sclerosis between 1993 and 2013

Dániel Sandi, Viktória Zsiros, Judit Füvesi, Zsigmond Tamás Kincses, Zsanett Fricska-Nagy, Gyula Lencsés, L. Vécsei, K. Bencsik

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective We aimed to assess the causes of death, the mortality and survival time of MS patients in Hungary. Patients and methods Between 1993 and 2013, 740 patients (10,303 person-years) were treated at our Outpatients' Clinic, of which 121 died. The causes of death were established from the pathological records or the medical certificates of the cause of death. The standardized mortality ratios (SMR) were calculated. Survival time was assessed with Gehan-Breslow test. Results Sixty-four percent of our patients died of MS-related causes. The SMR was 2.52. Primary progressive (PPMS) patients' SMR was higher (4.10) than initially relapsing patients' (RR/SPMS) was. There was no difference between the genders (2.46 for men vs 2.57 for women). The median survival time of woman was 3 years longer (p <0.001). RR/SPMS patients' median survival (35 years) was more than twice as long as PPMS patients' (14 years). Discussion The frequency of the MS-related cause of death, SMR and the median survival times were mostly similar to previous results from Scandinavia and North-America, despite the very different socio-economic backgrounds of these areas which shows that the survival risk can solely be attributed to MS itself. These are the first data on the topic from Central-Eastern-Europe.

Original languageEnglish
Pages (from-to)329-332
Number of pages4
JournalJournal of the Neurological Sciences
Volume367
DOIs
Publication statusPublished - Aug 15 2016

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Multiple Sclerosis
Mortality
Survival
Cause of Death
Scandinavian and Nordic Countries
Eastern Europe
Hungary
North America
Ambulatory Care Facilities
Medical Records
Economics

Keywords

  • Cause of death
  • Hungary
  • Mortality
  • Multiple sclerosis
  • Survival time

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Mortality in Hungarian patients with multiple sclerosis between 1993 and 2013. / Sandi, Dániel; Zsiros, Viktória; Füvesi, Judit; Kincses, Zsigmond Tamás; Fricska-Nagy, Zsanett; Lencsés, Gyula; Vécsei, L.; Bencsik, K.

In: Journal of the Neurological Sciences, Vol. 367, 15.08.2016, p. 329-332.

Research output: Contribution to journalArticle

Sandi D, Zsiros V, Füvesi J, Kincses ZT, Fricska-Nagy Z, Lencsés G et al. Mortality in Hungarian patients with multiple sclerosis between 1993 and 2013. Journal of the Neurological Sciences. 2016 Aug 15;367:329-332. https://doi.org/10.1016/j.jns.2016.06.035
Sandi, Dániel ; Zsiros, Viktória ; Füvesi, Judit ; Kincses, Zsigmond Tamás ; Fricska-Nagy, Zsanett ; Lencsés, Gyula ; Vécsei, L. ; Bencsik, K. / Mortality in Hungarian patients with multiple sclerosis between 1993 and 2013. In: Journal of the Neurological Sciences. 2016 ; Vol. 367. pp. 329-332.
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