Mortality in cancer patients previously diagnosed with herpes zoster in the hospital setting: A nationwide cohort study

S. A.J. Schmidt, G. V. Sørensen, E. Horváth-Puhó, L. Pedersen, N. Obel, K. L. Petersen, H. C. Schønheyder, H. T. Sørensen

Research output: Contribution to journalArticle

Abstract

Background:Herpes zoster (HZ) is associated with underlying immunodeficiency and may thereby predict mortality of subsequent cancer.Methods:By using Danish nationwide medical databases, we identified all cancer patients with a prior hospital-based HZ diagnosis during 1982-2011 (n=2754) and a matched cancer cohort without prior HZ (n=26 243). We computed adjusted mortality rate ratios (aMRRs) associating prior HZ with mortality following cancer.Results:Prior HZ was associated with decreased mortality within the year after cancer diagnosis (aMRR 0.87; 95% confidence interval (CI): 0.81-0.93), but not thereafter (aMRR 1.07; 95% CI: 0.99-1.15). However, prior HZ predicted increased mortality throughout the entire follow-up among patients aged <60 years (aMRR 1.39; 95% CI: 1.15-1.68) and those with disseminated HZ (aMRR 1.18; 95% CI: 1.01-1.37). The increased mortality rates were observed primarily for haematological and immune-related cancers.Conclusions:Overall, HZ was not a predictor of increased mortality following subsequent cancer.

Original languageEnglish
Pages (from-to)1822-1826
Number of pages5
JournalBritish journal of cancer
Volume112
Issue number11
DOIs
Publication statusPublished - May 26 2015

Keywords

  • cancer
  • epidemiology
  • herpes zoster
  • mortality
  • shingles

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Mortality in cancer patients previously diagnosed with herpes zoster in the hospital setting: A nationwide cohort study'. Together they form a unique fingerprint.

  • Cite this

    Schmidt, S. A. J., Sørensen, G. V., Horváth-Puhó, E., Pedersen, L., Obel, N., Petersen, K. L., Schønheyder, H. C., & Sørensen, H. T. (2015). Mortality in cancer patients previously diagnosed with herpes zoster in the hospital setting: A nationwide cohort study. British journal of cancer, 112(11), 1822-1826. https://doi.org/10.1038/bjc.2015.136