Morphometric changes of gray matter in Parkinson's disease with depression: A voxel-based morphometry study

Adam Feldmann, Zsolt Illes, Peter Kosztolanyi, Eniko Illes, Andrea Mike, Ferenc Kover, Istvan Balas, Norbert Kovacs, Ferenc Nagy

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

The origin of the high rate of depression in idiopathic Parkinson's disease (PD) is unknown. We applied voxel-based morphometry (VBM), as a sensitive tool in detection of gray matter MR density alterations, to find differences in depressed and nondepressed PD patients. Patients with idiopathic PD were classified into depressed (DPD) and nondepressed (NDPD) groups based on the Montgomery-Åsberg Depression Rating Scale (MADRS). Subsequently, a group comparisons were performed between depressed PD (n = 23), nondepressed PD (n = 27) and normal healthy controls (NC, n = 16). There was no difference in gray matter density comparing healthy controls to any PD groups. However, when NDPD and DPD cohorts were compared, density alteration of the bilateral orbitofrontal, bilateral rectal gyrus, and also the right superior temporal pole was detected in the depressed subgroup. Exploratory analyses revealed an inverse correlation of MADRS scores and severity of VBM alteration in these regions beside the right medial temporal gyrus, anterior and medial cingular gyrus, and parahippocampal gyrus. These results suggest that depression in PD is related to gray matter decrease in the bilateral orbitofrontal and right temporal regions as well as the limbic system.

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalMovement Disorders
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 15 2008

Keywords

  • Cingular cortex
  • Depression
  • Orbitofrontal gray matter changing
  • Parkinson's disease
  • Parkinsonian depression
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Feldmann, A., Illes, Z., Kosztolanyi, P., Illes, E., Mike, A., Kover, F., Balas, I., Kovacs, N., & Nagy, F. (2008). Morphometric changes of gray matter in Parkinson's disease with depression: A voxel-based morphometry study. Movement Disorders, 23(1), 42-46. https://doi.org/10.1002/mds.21765