Morphological, thermoanalytical and crystallographic study of different sulphadimidine crystals

M. Shourbaji, K. Pintye-Hódi, Cs Novák, J. Madarász, P. Szabó-Révész, P. Kása, J. Eros, S. Gál

Research output: Contribution to journalArticle

Abstract

The sulphonamide antibacterials including Sulphadimidine as a short-acting drug is well absorbed from the gastrointestinal tract, and 80 to 90% of it is bound to the plasma protein. The commercial products exhibit various morphologies that influence the preparation of the solid dosage forms. The powder mixture must have adequate flowability and compactibility during direct compression and capsule filling. These properties are influenced by the morphological parameters of the particles, and are additionally important in the preparation of granules as concerns the distribution of the drug particles. The aim of the present work was to compare the morphological, thermoanalytical and structural properties of sulphadimidine samples obtained from three different batches.

Original languageEnglish
Pages (from-to)221-226
Number of pages6
JournalHungarian Journal of Industrial Chemistry
Volume27
Issue number3
Publication statusPublished - Dec 1 1999

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ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Chemistry(all)
  • Chemical Engineering(all)

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