Morphological observations in brain arteriovenous malformations after gamma knife radiosurgery

G. Szeifert, Marc Levivier, José Lorenzoni, I. Nyáry, Ottó Major, Andras A. Kemeny

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Citations (Scopus)

Abstract

Morphological studies after Gamma Knife radiosurgery (GKRS) revealed endothelial destruction followed by spindle-shaped cell proliferation in the subendothelial region and in the connective tissue stroma of arteriovenous malformation (AVM) vessels. Histological, immunohistochemical and ultra structural characteristics of this spindle-shaped cell population in the irradiated AVMs were reminicent of those described as myofibroblasts in wound healing processes and pathological fibromatoses. These modified fibroblasts have contractile capacity, therefore this might contribute to the vessel occlusion, shrinking process and final volume reduction of AVMs after GKRS. Similar histopathological changes were observed in a cavernous malformation following high-dose irradiation.

Original languageEnglish
Title of host publicationGamma Knife Radiosurgery for Brain Vascular Malformations
PublisherS. Karger AG
Pages119-129
Number of pages11
Volume27
ISBN (Print)9783805596206, 9783805596190
DOIs
Publication statusPublished - Dec 12 2012

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Szeifert, G., Levivier, M., Lorenzoni, J., Nyáry, I., Major, O., & Kemeny, A. A. (2012). Morphological observations in brain arteriovenous malformations after gamma knife radiosurgery. In Gamma Knife Radiosurgery for Brain Vascular Malformations (Vol. 27, pp. 119-129). S. Karger AG. https://doi.org/10.1159/000341772