Morphological changes in the hypothalamo-pituitary-adrenal system during early postnatal period in rats

M. Palkovits, A. Mitro

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The administration of ACTH, DOCA, hydrocortisone or formalin-induced stress on the day of birth, or during the postnatal period, causes the same reaction in the adrenal gland of neonatal rats as in adult animals. An enlargement of the adrenal cortex, and a significant increase in the nuclear volume in the fascicular zone, as well as a less pronounced increase in the glomerularzzone, was found both in the ACTH-treated animals and in those treated with formalin. Opposite changes were observed after hydrocortisone administration. DOCA, however, induced remarkable changes in both the glomerular and fascicular zones, suggesting a deerease of their function. Qualitative and quantitative changes occurred also in the so-called "hypophysiotropic area" of the hypothalamus. ACTH, DOCA, hydrocortisone, stress-induced irregularity, and atrophy of cells decreased the volume of nuclei in this area. These changes could not be observed in other regions of the hypothalamus.

Original languageEnglish
Pages (from-to)253-262
Number of pages10
JournalGeneral and Comparative Endocrinology
Volume10
Issue number2
DOIs
Publication statusPublished - Apr 1968

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology

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