Morphological basis of sensory neuropathy and neuroimmunomodulation in minor salivary glands of patients with Sjögren's syndrome

B. Batbayar, G. Nagy, G. Kövesi, T. Zelles, E. Fehér

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: A predominance of sensory neuropathy was earlier described in Sjögren's syndrome (SS), which might precede the presence of sicca symptoms. The mechanism of sensory neuropathy in SS is unknown. Therefore, the aim of this study was to determine the quantitative changes of the different neuropeptide containing nerve terminals and the immunocompetent cells in labial salivary glands of primary SS. Design: Immunohisto- and immunocytochemical methods were used for the detection of immunoreactive (IR) elements and the data were compared with the healthy controls. Results: All of the investigated IR nerve fibres were found in different quantity and localisation in both of control and SS glands. The density of them was changed variously in SS. The number of the substance P (SP), neuropeptide Y (NPY) (P

Original languageEnglish
Pages (from-to)529-538
Number of pages10
JournalArchives of Oral Biology
Volume49
Issue number7
DOIs
Publication statusPublished - Jul 2004

Fingerprint

Neuroimmunomodulation
Minor Salivary Glands
Neuropeptide Y
Substance P
Lip
Salivary Glands
Neuropeptides
Nerve Fibers

Keywords

  • Immunocytes
  • Neuroimmunomodulation
  • Neuropeptides
  • Salivary glands
  • Sensory neuropathy
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

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abstract = "Objective: A predominance of sensory neuropathy was earlier described in Sj{\"o}gren's syndrome (SS), which might precede the presence of sicca symptoms. The mechanism of sensory neuropathy in SS is unknown. Therefore, the aim of this study was to determine the quantitative changes of the different neuropeptide containing nerve terminals and the immunocompetent cells in labial salivary glands of primary SS. Design: Immunohisto- and immunocytochemical methods were used for the detection of immunoreactive (IR) elements and the data were compared with the healthy controls. Results: All of the investigated IR nerve fibres were found in different quantity and localisation in both of control and SS glands. The density of them was changed variously in SS. The number of the substance P (SP), neuropeptide Y (NPY) (P",
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AU - Batbayar, B.

AU - Nagy, G.

AU - Kövesi, G.

AU - Zelles, T.

AU - Fehér, E.

PY - 2004/7

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N2 - Objective: A predominance of sensory neuropathy was earlier described in Sjögren's syndrome (SS), which might precede the presence of sicca symptoms. The mechanism of sensory neuropathy in SS is unknown. Therefore, the aim of this study was to determine the quantitative changes of the different neuropeptide containing nerve terminals and the immunocompetent cells in labial salivary glands of primary SS. Design: Immunohisto- and immunocytochemical methods were used for the detection of immunoreactive (IR) elements and the data were compared with the healthy controls. Results: All of the investigated IR nerve fibres were found in different quantity and localisation in both of control and SS glands. The density of them was changed variously in SS. The number of the substance P (SP), neuropeptide Y (NPY) (P

AB - Objective: A predominance of sensory neuropathy was earlier described in Sjögren's syndrome (SS), which might precede the presence of sicca symptoms. The mechanism of sensory neuropathy in SS is unknown. Therefore, the aim of this study was to determine the quantitative changes of the different neuropeptide containing nerve terminals and the immunocompetent cells in labial salivary glands of primary SS. Design: Immunohisto- and immunocytochemical methods were used for the detection of immunoreactive (IR) elements and the data were compared with the healthy controls. Results: All of the investigated IR nerve fibres were found in different quantity and localisation in both of control and SS glands. The density of them was changed variously in SS. The number of the substance P (SP), neuropeptide Y (NPY) (P

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